Tg(Thy1-MAPT)183Gotz
Transgene Detail

Summary

• Symbol: Tg(Thy1-MAPT)183Gotz
• Name: transgene insertion 183, Jurgen Gotz
• MGI ID: MGI:2672839
• Synonyms: P301L tau, pR5
• Transgene: Tg(Thy1-MAPT)183Gotz Location: unknown
• Alliance: Tg(Thy1-MAPT)183Gotz page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA/2)F2

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Thy1-MAPT)183Gotz expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: Sequence encoding the longest human MAPT brain isoform (tau40), consisting of exons 2 and 3 as well as four microtubule-binding repeats, was adjoined to the murine Thy1 promoter. The human MAPT sequence included the P301L point mutation, which is linked to human frontotemporal dementia with parkinsonism. Soluble levels of transgenic protein in the brain were approximately 70% of the endogenous level. Expression levels of transgenic protein were high in the hippocampus, fornix fimbriae, amygdala, spinal cord, and cortex, weaker in brain stem and striatum, and not detectable in the olfactory bulb and cerebellum. (J:66831)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:66831 Gotz J, et al., Tau filament formation in transgenic mice expressing P301L tau. J Biol Chem. 2001 Jan 5;276(1):529-34
• All: 35 reference(s)