Tg(Tuba1-MAPT)14Vle
Transgene Detail

Summary

• Symbol: Tg(Tuba1-MAPT)14Vle
• Name: transgene insertion 14, Virginia M Y Lee
• MGI ID: MGI:2385585
• Synonyms: Talpha1-3RT
• Transgene: Tg(Tuba1-MAPT)14Vle Location: unknown
• Alliance: Tg(Tuba1-MAPT)14Vle page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(Tuba1-MAPT)14Vle expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  MAPT (4137)

  Mapt	(MGI:97180)

• Mutation details: A murine Tuba1 promoter was adjoined to a minigene comprised of the complete coding region of the MAPT gene that included modified intronic sequence flanking exons 2 and 3 to drive expression of the downstream gene construct in the CNS. Western blot analysis showed the MAPT protein to be expressed at levels approximately 5.5 fold higher than the endogenous mouse counterpart. (J:78400)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:78400 Higuchi M, et al., Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration. Neuron. 2002 Aug 1;35(3):433-46
• All: 2 reference(s)