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Sh2d1b2 Gene Detail
Summary
  • Symbol
    Sh2d1b2
  • Name
    SH2 domain containing 1B2
  • Synonyms
    Eat2b, Ert, Sh2d1c
  • Feature Type
    protein coding gene
  • IDs
    MGI:3622649
    NCBI Gene: 545378
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr1:170060440-170079156 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 76.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    602 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3622649
 protein coding gene Chr1:170060318-170081177 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016727
 protein coding gene Chr1:175925911-175949320 (+)
A/J MGP_AJ_G0016707
 protein coding gene Chr1:168748714-168773336 (+)
AKR/J MGP_AKRJ_G0016673
 protein coding gene Chr1:173816416-173869426 (+)
BALB/cJ MGP_BALBcJ_G0016668
 protein coding gene Chr1:169232238-169259269 (+)
C3H/HeJ MGP_C3HHeJ_G0016492
 protein coding gene Chr1:174062995-174086454 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017129
 protein coding gene Chr1:181752589-181775952 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014838
 protein coding gene Chr1:160489573-160508522 (+)
CAST/EiJ MGP_CASTEiJ_G0016072
 protein coding gene Chr1:173695235-173718470 (+)
CBA/J MGP_CBAJ_G0016467
 protein coding gene Chr1:188212645-188240100 (+)
DBA/2J MGP_DBA2J_G0016573
 protein coding gene Chr1:167612455-167665176 (+)
FVB/NJ no annotation
LP/J MGP_LPJ_G0016644
 protein coding gene Chr1:177009472-177014939 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016596
 protein coding gene Chr1:195551417-195572362 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017166
 protein coding gene Chr1:173704535-173725606 (+)
PWK/PhJ MGP_PWKPhJ_G0015858
 protein coding gene Chr1:166842046-166869058 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0016134
 protein coding gene Chr1:173827681-173851387 (+)



Homology
more
  • Human Ortholog
    SH2D1B, SH2 domain containing 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SH2D1B, SH2 domain containing 1B
  • Synonyms
    EAT2
  • Links
    NCBI Gene ID: 117157
    neXtProt AC: NX_O14796
    UniProt: O14796

  • Chr Location
    1q23.3; chr1:162395268-162412138 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 4 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    2
  • Endonuclease-mediated
    3
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    2 involving Sh2d1b2
  • Find Mice (IMSR)
    8 strains or lines available
Homozygous mutation of this gene results in altered natural killer cell function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 545378 NCBI Gene Model | MGI Sequence Detail 18717 C57BL/6J ±  kb
transcript NM_001033499 RefSeq | MGI Sequence Detail 399 129/Sv  
polypeptide Q45HK4 UniProt | EBI | MGI Sequence Detail 132 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 27
    Gene Ontology 7
    Phenotypes 15
  • Earliest
    J:110195 Roncagalli R, et al., Negative regulation of natural killer cell function by EAT-2, a SAP-related adaptor. Nat Immunol. 2005 Oct;6(10):1002-10
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory