Srilp QTL Detail

Summary

• Symbol
  Srilp
• Name
  sleep response to influenza, light phase
• Synonyms
  Srilp1

• Feature Type
  QTL
• IDs
  MGI:3622817
  NCBI Gene: 100035300
• Candidate Genes
  1 Gene

Location &
Maps

• Sequence Map
  Chr6:48703490-75424693 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 6, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  2 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotype references
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Sequences &
Gene Models

• NCBI Gene
  100035300

References

• Summaries
  All 3

  Phenotypes 2
• Earliest
  J:61415 Toth LA, et al., A quantitative genetic analysis of slow-wave sleep in influenza-infected CXB recombinant inbred mice. Behav Genet. 1999 Sep;29(5):339-48
• Latest
  J:106977 Ding M, et al., mRNA expression in mouse hypothalamus and basal forebrain during influenza infection: a novel model for sleep regulation. Physiol Genomics. 2006 Feb 14;24(3):225-34

Candidate Genes for Srilp:

Gene	Genome Location (GRCm39)	Reference	QTL Note
Inmt	Chr6:55147612-55151975 (-)	J:106977	Inmt (a.k.a. Temt) was proposed as a novel candidate gene for previously identified QTL Srilp (sleep response to influenze, light phase) on mouse Chromosome 6. Gene expression analysis of influenza-infected animals showed significantly varied dark-light phase Inmt mRNA expression in the hypothalamus and basal forebrain of high sleep response strain C57BL/6J, but not in low sleep response strain BALB/cByJ. Expression of several other Srilp candidate genes (Ghrhr, Crhr2, Npy, Adcyap1r1) were also examined but none were expressed differently between influenza-infected BALB/cByJ and C57BL/6J animals. Sequence analysis of Inmt revealed a conservative single nucleotide substitution at position 95. However, the strain distribution pattern of this polymorphism does not correlate with the Srilp phenotype. Several other intronic SNPs were also identified in Inmt and Crhr2 sequences. Authors suggest it is unlikely that Inmt is the gene underlying Srilp. However, the 95% confidence interval of Srilp was localized to 28 cM - 31 cM. Srilp accounts for 35%-45% of the phenotypic variance.