Tg(Ckm-LPL)HRze
Transgene Detail

Summary

• Symbol: Tg(Ckm-LPL)HRze
• Name: transgene insertion H, Rudolf Zechner
• MGI ID: MGI:3624978
• Synonyms: MCK-H
• Transgene: Tg(Ckm-LPL)HRze Location: unknown
• Alliance: Tg(Ckm-LPL)HRze page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Ckm-LPL)HRze expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  LPL (4023)

  Lpl	(MGI:96820)

• Mutation details: This transgene consists of an LPL minigene containing the full-length human LPL cDNA including the 5' untranslated sequence, the complete coding region, the 3' untranslated sequence, and 339 bp of 3' flanking region under the control of the mouse muscle creatine kinase promoter. This line integrated an estimated number of 20 copies per genome and is the high expression line. Human LPL is expressed in skeletal and cardiac muscle but not other tissues and there is a 24.4-fold increase in heparin releasable LPL activity in skeletal muscle. (J:101818)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:101818 Levak-Frank S, et al., Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice. J Clin Invest. 1995 Aug;96(2):976-86
• All: 4 reference(s)