Mir497 MGI Mouse Gene Detail - MGI:3629886

Symbol

Mir497
Name

microRNA 497
Synonyms

Mirn497, mmu-mir-497

Feature Type

miRNA gene
IDs

MGI:3629886
NCBI Gene: 751537
Member of

Mirc27 cluster
Alliance

gene page

Sequence Map

Chr11:70125543-70125626 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.99 cM
Mapping Data

1 experiment

SNPs within 2kb

24 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3629886	miRNA gene	Chr11:70125543-70125626 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0007830	miRNA gene	Chr11:70755259-70755342 (+)
A/J	MGP_AJ_G0007826	miRNA gene	Chr11:68066572-68066655 (+)
AKR/J	MGP_AKRJ_G0007800	miRNA gene	Chr11:70097054-70097137 (+)
BALB/cJ	MGP_BALBcJ_G0007803	miRNA gene	Chr11:68389349-68389432 (+)
C3H/HeJ	MGP_C3HHeJ_G0007750	miRNA gene	Chr11:70135420-70135503 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0007981	miRNA gene	Chr11:72853358-72853441 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0007126	miRNA gene	Chr11:64985111-64985194 (+)
CAST/EiJ	MGP_CASTEiJ_G0007643	miRNA gene	Chr11:70381029-70381112 (+)
CBA/J	MGP_CBAJ_G0007721	miRNA gene	Chr11:76163718-76163801 (+)
DBA/2J	MGP_DBA2J_G0007757	miRNA gene	Chr11:67642314-67642397 (+)
FVB/NJ	MGP_FVBNJ_G0007774	miRNA gene	Chr11:67297820-67297903 (+)
LP/J	MGP_LPJ_G0007834	miRNA gene	Chr11:71324957-71325040 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0007744	miRNA gene	Chr11:76731881-76731964 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0007979	miRNA gene	Chr11:70368856-70368939 (+)
PWK/PhJ	MGP_PWKPhJ_G0007572	miRNA gene	Chr11:68296203-68296286 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0007468	miRNA gene	Chr11:70166734-70166817 (+)
WSB/EiJ	MGP_WSBEiJ_G0007711	miRNA gene	Chr11:70032286-70032369 (+)

Human Ortholog

MIR497, microRNA 497

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR497, microRNA 497
Synonyms

hsa-mir-497, mir-497, MIRN497
Links

HGNC:32088

NCBI Gene ID: 574456
Chr Location

chr17:7017911-7018022 (-) GRCh38

MGI Vertebrate Homology

Mir497 stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: MIR497
Gene Tree

Mir497

Diseases

1 with human MIR497 associations

				Human Disease	Mouse Models
				lung squamous cell carcinoma IDs lung squamous cell carcinoma DOID:3907 NCI:C3493 UMLS_CUI:C0149782

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

8 phenotype references

All Mutations and Alleles

2
Chemically induced (other)

1
Targeted

1
Genomic Mutations

2 involving Mir497
Find Mice (IMSR)

2 strains or lines available

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All GO Annotations

3
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

15
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

23
RefSeq

1

Ensembl

ENSMUSG00000105220 (Evidence)
NCBI Gene

751537

Representative Sequences				Length	Strain/Species	Flank
	genomic	751537	NCBI Gene Model \| MGI Sequence Detail	84	C57BL/6J	± kb
	transcript	NR_030444	RefSeq \| MGI Sequence Detail	84	C57BL/6

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All nucleic 3

Primer pair 1

Other 2

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miRBase

MI0004636

Summaries

All 27

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 8
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:357958 Zhang M, et al., MicroRNA-497 inhibits inflammation in DSS-induced IBD model mice and lipopolysaccharide-induced RAW264.7 cells via Wnt/beta-catenin pathway. Int Immunopharmacol. 2021 Dec;101(Pt B):108318

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24