Mir92-1 MGI Mouse Gene Detail - MGI:3629918

Symbol

Mir92-1
Name

microRNA 92-1
Synonyms

mir 92-1, Mirn92-1, mmu-mir-92-1, mmu-mir-92a-1

Feature Type

miRNA gene
IDs

MGI:3629918
NCBI Gene: 751549
Member of

Mirc1 cluster
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr14:115281859-115281938 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 14, 59.40 cM
Mapping Data

2 experiments

SNPs within 2kb

97 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3629918	miRNA gene	Chr14:115281859-115281938 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0008156	miRNA gene	Chr14:112498734-112498813 (+)
A/J	MGP_AJ_G0008144	miRNA gene	Chr14:108247291-108247370 (+)
AKR/J	MGP_AKRJ_G0008123	miRNA gene	Chr14:111782421-111782500 (+)
BALB/cJ	MGP_BALBcJ_G0008127	miRNA gene	Chr14:108764251-108764330 (+)
C3H/HeJ	MGP_C3HHeJ_G0008070	miRNA gene	Chr14:111608612-111608691 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0008318	miRNA gene	Chr14:116828214-116828293 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0007401	miRNA gene	Chr14:104418637-104418714 (+)
CAST/EiJ	MGP_CASTEiJ_G0007945	miRNA gene	Chr14:109386418-109386497 (+)
CBA/J	MGP_CBAJ_G0008038	miRNA gene	Chr14:121367450-121367529 (+)
DBA/2J	MGP_DBA2J_G0008074	miRNA gene	Chr14:108168894-108168973 (+)
FVB/NJ	MGP_FVBNJ_G0008098	miRNA gene	Chr14:106514153-106514232 (+)
LP/J	MGP_LPJ_G0008154	miRNA gene	Chr14:113526159-113526238 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0008065	miRNA gene	Chr14:126245209-126245288 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0008313	miRNA gene	Chr14:111208338-111208417 (+)
PWK/PhJ	MGP_PWKPhJ_G0007867	miRNA gene	Chr14:105114876-105114955 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0007762	miRNA gene	Chr14:107345925-107346002 (+)
WSB/EiJ	MGP_WSBEiJ_G0008023	miRNA gene	Chr14:111952662-111952741 (+)

Human Ortholog

MIR92A1, microRNA 92a-1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR92A1, microRNA 92a-1
Synonyms

C13orf25, MIR17HG, MIR92-1, mir-92a-1, MIRH1, MIRHG1, MIRN92-1, MIRN92A-1, MIRN92A1, miRNA92-1
Links

HGNC:31643

NCBI Gene ID: 407048
Chr Location

chr13:91351314-91351391 (+) GRCh38

MGI Vertebrate Homology

Mir92-1 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: MIR92A1
Gene Tree

Mir92-1

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Phenotype Summary

13 phenotypes from 3 alleles in 3 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

4
Genomic Mutations

3 involving Mir92-1
Find Mice (IMSR)

4 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit partial postnatal lethality, decreased body weight, length and size, brachyphalangia, short tibia, and a small cranium.

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All GO Annotations

58
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

797
Tissues

60
Literature Summary

20

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

23
RefSeq

1

Ensembl

ENSMUSG00000076062 (Evidence)
NCBI Gene

751549

Representative Sequences				Length	Strain/Species	Flank
	genomic	751549	NCBI Gene Model \| MGI Sequence Detail	80	C57BL/6J	± kb
	transcript	NR_029816	RefSeq \| MGI Sequence Detail	80	C57BL/6

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All nucleic 8

Primer pair 6

Other 2

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miRBase

MI0000719

Summaries

All 55

Developmental Gene Expression 20

Gene Ontology 8

Phenotypes 11
Earliest

J:67314 Roix J, et al., Molecular and functional mapping of the piebald deletion complex on mouse chromosome 14. Genetics. 2001 Feb;157(2):803-15
Latest

J:343259 Winkler I, et al., MicroRNA-92a-CPEB3 axis protects neurons against inflammatory neurodegeneration. Sci Adv. 2023 Nov 24;9(47):eadi6855

TSS for Mir92-1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr127131	Chr14:115281929-115281932 (+)	72 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24