Mir146b MGI Mouse Gene Detail - MGI:3629945

Symbol

Mir146b
Name

microRNA 146b
Synonyms

mir 146b, Mirn146b, mmu-mir-146b

Feature Type

miRNA gene
IDs

MGI:3629945
NCBI Gene: 751550
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr19:46331201-46331309 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 38.82 cM
Mapping Data

1 experiment

SNPs within 2kb

97 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3629945	miRNA gene	Chr19:46331201-46331309 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0008450	miRNA gene	Chr19:46024970-46025078 (+)
A/J	MGP_AJ_G0008438	miRNA gene	Chr19:43759440-43759548 (+)
AKR/J	no annotation
BALB/cJ	MGP_BALBcJ_G0008425	miRNA gene	Chr19:43818232-43818340 (+)
C3H/HeJ	MGP_C3HHeJ_G0008368	miRNA gene	Chr19:45345026-45345134 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0008628	miRNA gene	Chr19:47175002-47175110 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0007646	miRNA gene	Chr19:42997387-42997495 (+)
CAST/EiJ	MGP_CASTEiJ_G0008225	miRNA gene	Chr19:45143775-45143883 (+)
CBA/J	MGP_CBAJ_G0008333	miRNA gene	Chr19:49530248-49530356 (+)
DBA/2J	MGP_DBA2J_G0008368	miRNA gene	Chr19:43582409-43582517 (+)
FVB/NJ	MGP_FVBNJ_G0008389	miRNA gene	Chr19:43359591-43359699 (+)
LP/J	MGP_LPJ_G0008453	miRNA gene	Chr19:45934032-45934140 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0008353	miRNA gene	Chr19:48873517-48873625 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0008618	miRNA gene	Chr19:45283778-45283882 (+)
PWK/PhJ	MGP_PWKPhJ_G0008149	miRNA gene	Chr19:43529540-43529648 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0008023	miRNA gene	Chr19:43937884-43937992 (+)
WSB/EiJ	MGP_WSBEiJ_G0008309	miRNA gene	Chr19:45426925-45427033 (+)

Human Ortholog

MIR146B, microRNA 146b

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MIR146B, microRNA 146b
Synonyms

mir-146b, MIRN146B, miRNA146B
Links

HGNC:32079

NCBI Gene ID: 574447
Chr Location

chr10:102436512-102436584 (+) GRCh38

MGI Vertebrate Homology

Mir146b stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: MIR146B
Gene Tree

Mir146b

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
3 phenotypes from multigenic genotypes
2 phenotype references

All Mutations and Alleles

2
Targeted

2
Find Mice (IMSR)

2 strains or lines available

Mice homozygous for a conditional allele activated in T cells exhibit normal humoral response. However, in conjuction with an Mir146 contional allele, exhibit exaccerbated increases of germinal B and T follicular helper cells.

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All GO Annotations

5
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
Literature Summary

4

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

22
RefSeq

1

Ensembl

ENSMUSG00000070127 (Evidence)
NCBI Gene

751550

Representative Sequences				Length	Strain/Species	Flank
	genomic	751550	NCBI Gene Model \| MGI Sequence Detail	109	C57BL/6J	± kb
	transcript	NR_030468	RefSeq \| MGI Sequence Detail	109	C57BL/6

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All nucleic 1

Other 1

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miRBase

MI0004665

Summaries

All 21

Developmental Gene Expression 4

Gene Ontology 5

Phenotypes 2
Earliest

J:105741 Griffiths-Jones S, et al., miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 2006 Jan 1;34(Database issue):D140-4
Latest

J:311113 Santeford A, et al., Loss of Mir146b with aging contributes to inflammation and mitochondrial dysfunction in thioglycollate-elicited peritoneal macrophages. Elife. 2021 Aug 23;10:e66703

TSS for Mir146b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr156747	Chr19:46329557-46329561 (+)	-1,642 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24