Dok6 MGI Mouse Gene Detail - MGI:3639495

Symbol

Dok6
Name

docking protein 6
Synonyms

Dok-6

Feature Type

protein coding gene
IDs

MGI:3639495
NCBI Gene: 623279
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr18:89310548-89787652 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 59.05 cM
Mapping Data

1 experiment

SNPs within 2kb

11154 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3639495	protein coding gene	Chr18:89310547-89787664 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024618	protein coding gene	Chr18:90655074-91149405 (-)
A/J	MGP_AJ_G0024585	protein coding gene	Chr18:86613126-87075558 (-)
AKR/J	MGP_AKRJ_G0024556	protein coding gene	Chr18:89219090-89673367 (-)
BALB/cJ	MGP_BALBcJ_G0024583	protein coding gene	Chr18:86895497-87372072 (-)
C3H/HeJ	MGP_C3HHeJ_G0024352	protein coding gene	Chr18:89374767-89872877 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025031	protein coding gene	Chr18:92970567-93483057 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022461	protein coding gene	Chr18:85339842-85761072 (-)
CAST/EiJ	MGP_CASTEiJ_G0023824	protein coding gene	Chr18:89853260-90348152 (-)
CBA/J	MGP_CBAJ_G0024322	protein coding gene	Chr18:96286000-96820499 (-)
DBA/2J	MGP_DBA2J_G0024451	protein coding gene	Chr18:86175742-86656995 (-)
FVB/NJ	MGP_FVBNJ_G0024418	protein coding gene	Chr18:85496137-85941360 (-)
LP/J	MGP_LPJ_G0024536	protein coding gene	Chr18:90518544-91021132 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024448	protein coding gene	Chr18:98164396-98776458 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025079	protein coding gene	Chr18:89521156-90005571 (-)
PWK/PhJ	MGP_PWKPhJ_G0023570	protein coding gene	Chr18:86531547-87003087 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023377	protein coding gene	Chr18:89501506-89957355 (-)
WSB/EiJ	MGP_WSBEiJ_G0023887	protein coding gene	Chr18:89425722-89914424 (-)

Human Ortholog

DOK6, docking protein 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

DOK6, docking protein 6
Synonyms

DOK5L, HsT3226
Links

HGNC:28301

NCBI Gene ID: 220164

neXtProt AC: NX_Q6PKX4

UniProt: Q6PKX4
Chr Location

18q22.2; chr18:69400888-69849087 (+) GRCh38

MGI Vertebrate Homology

Dok6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: DOK6
Gene Tree

Dok6

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Spontaneous

1
Targeted

2
Genomic Mutations

1 involving Dok6
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

3
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

780
Tissues

14
cDNA Data

6
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase dok6

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS37878.1

Ensembl

ENSMUSG00000073514 (Evidence)
NCBI Gene

623279

			Length	Strain/Species	Flank
genomic	ENSMUSG00000073514	Ensembl Gene Model \| MGI Sequence Detail	477105	C57BL/6J	± kb
transcript	ENSMUST00000097495	Ensembl \| MGI Sequence Detail	10099	Not Applicable
polypeptide	ENSMUSP00000095103	Ensembl \| MGI Sequence Detail	331	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000006633 docking protein 6

(term hierarchy)
InterPro Domains

IPR050996 Docking Protein Family (DOK)

IPR037816 DOK4/5/6, PH domain

IPR002404 IRS-type PTB domain

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

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All nucleic 7

cDNA 6

Primer pair 1

Microarray probesets 1

Summaries

All 22

Developmental Gene Expression 5

Gene Ontology 2

Phenotypes 7
Earliest

J:45709 Melloy PG, et al., No turning, a mouse mutation causing left-right and axial patterning defects. Dev Biol. 1998 Jan 1;193(1):77-89
Latest

J:345844 Guo Y, et al., Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy. Signal Transduct Target Ther. 2024 Feb 14;9(1):32

TSS for Dok6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154167	Chr18:89787603-89787682 (-)	9 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24