Tg(Myh6-Acsl1)O7Jesc
Transgene Detail

Summary

• Symbol: Tg(Myh6-Acsl1)O7Jesc
• Name: transgene insertion O7, Jean E Schaffer
• MGI ID: MGI:3639517
• Synonyms: MHC-ACS O7
• Transgene: Tg(Myh6-Acsl1)O7Jesc Location: unknown
• Alliance: Tg(Myh6-Acsl1)O7Jesc page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Acsl1)O7Jesc expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Acsl1 (MGI:102797)

• Tg(Myh6-Acsl1)O7Jesc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Myh6 (MGI:97255)

• Mutation details: The murine adipocyte Acsl1 cDNA containing a Myc tag is under the control of an alpha-mysoin heavy chain promoter construct that contains the last exon of the beta-myosin heavy chain gene, the alpha-myosin heavy chain promoter, and the first three untranslated exons of the alpha-myosin heavy chain gene. See an 11-fold increase in Acsl1 protein specifically in the heart. (J:68639)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:68639 Chiu HC, et al., A novel mouse model of lipotoxic cardiomyopathy. J Clin Invest. 2001 Apr;107(7):813-22
• All: 7 reference(s)