Tg(Tyr-cre/ERT2)13Bos
Transgene Detail

Summary

• Symbol: Tg(Tyr-cre/ERT2)13Bos
• Name: transgene insertion 13, Marcus Bosenberg
• MGI ID: MGI:3641203
• Synonyms: Tyr::CreER, Tyr::CreER^T2, Tyr::CreER^T2-Bos
• Transgene: Tg(Tyr-cre/ERT2)13Bos Location: unknown Genetic Position: Chr2, Syntenic
• Alliance: Tg(Tyr-cre/ERT2)13Bos page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutations: Insertion, Intergenic deletion
• Tg(Tyr-cre/ERT2)13Bos expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Tyr

• Mutation details: This transgene consists of a 5.5 kb fragment of the Tyr promoter and a 3.6 kb fragment of the Tyr enhancer driving expression of a tamoxifen-inducible form of cre recombinase. 3 lines were generated which all showed tamoxifen-inducible Cre activity in cutaneous melanocytes. This is a representative record for all 3 lines. Line 13 contains 2 copies of the transgene inserted into chromosome 2 (chr2:129,989,606; NCBI37/mm9) 7.8 kb downstream of Snrpb and 9.6 kb downstream of Tgm6 with a 3 kb deletion at the integration site. In addition, three or more copies of the transgene were integrated on chromosome 2 resulting in ~3 kb deletion of this intergenic region between base pairs 130,160,936 and 130,163,877 [mouse mm10]. (J:110143, J:240920, J:282623)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tyr (species not specified) Summary of all recombinase alleles driven by Tyr. Comparative matrix view of recombinase activities

Disease models

Tumor Data

List all tumor models in MMHCdb carrying Tg(Tyr-cre/ERT2)13Bos

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 12 strains available Cell Lines: 0 lines available

References

• Original: J:110143 Bosenberg M, et al., Characterization of melanocyte-specific inducible Cre recombinase transgenic mice. Genesis. 2006 May;44(5):262-7
• All: 160 reference(s)