Gpr52 MGI Mouse Gene Detail - MGI:3643278 - G protein-coupled receptor 52

Gpr52 Gene Detail

Symbol

Gpr52
Name

G protein-coupled receptor 52
Synonyms

EG620246

Feature Type

protein coding gene
IDs

MGI:3643278
NCBI Gene: 620246
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr1:160403908-160405544 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 69.75 cM
Mapping Data

1 experiment

SNPs within 2kb

58 from dbSNP Build 142
Strain Annotations

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3643278	protein coding gene	Chr1:160402287-160407274 (-)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

GPR52, G protein-coupled receptor 52

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPR52, G protein-coupled receptor 52
Links

HGNC:4508

NCBI Gene ID: 9293

neXtProt AC: NX_Q9Y2T5

UniProt: Q9Y2T5
Chr Location

1q25.1; chr1:174447964-174449545 (+) GRCh38

MGI Vertebrate Homology

Gpr52 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: GPR52
Gene Tree

Gpr52

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Phenotype Summary

6 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

2
Endonuclease-mediated

2
Targeted

1
Genomic Mutations

2 involving Gpr52
Find Mice (IMSR)

2 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a knock-out allele exhibit decreased anxiety response in an open field test and increased startle response when treated with MK-801.

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All GO Annotations

13
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpr52

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All Sequences

10
RefSeq

4
UniProt

1
CCDS

CCDS87900.1

Ensembl

ENSMUSG00000118401 (Evidence)
NCBI Gene

620246

			Length	Strain/Species	Flank
genomic	ENSMUSG00000118401	Ensembl Gene Model \| MGI Sequence Detail	1637	C57BL/6J	± kb
transcript	ENSMUST00000238289	Ensembl \| MGI Sequence Detail	1637	Not Applicable
polypeptide	ENSMUSP00000158769	Ensembl \| MGI Sequence Detail	361	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001646 G-protein coupled receptor 52

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR050125 G-protein coupled receptor opsins

IPR000276 G protein-coupled receptor, rhodopsin-like
GlyGen

P0C5J4 3 sites

Summaries

All 20

Gene Ontology 7

Phenotypes 7
Earliest

J:214470 Komatsu H, et al., Anatomical transcriptome of G protein-coupled receptors leads to the identification of a novel therapeutic candidate GPR52 for psychiatric disorders. PLoS One. 2014;9(2):e90134
Latest

J:336265 Krieg PF, et al., GPR52 regulates cAMP in T cells but is dispensable for encephalitogenic responses. Front Immunol. 2022;13:1113348

TSS for Gpr52:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr14554	Chr1:160405463-160405474 (-)	75 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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