Cntnap5a MGI Mouse Gene Detail - MGI:3643623 - contactin associated protein-like 5A

Symbol

Cntnap5a
Name

contactin associated protein-like 5A
Synonyms

Caspr5-1

Feature Type

protein coding gene
IDs

MGI:3643623
NCBI Gene: 636808
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr1:115612486-116515053 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 51.59 cM
Mapping Data

1 experiment

SNPs within 2kb

29763 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3643623	protein coding gene	Chr1:115612467-116515053 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016388	protein coding gene	Chr1:118220961-119180213 (+)
A/J	MGP_AJ_G0016368	protein coding gene	Chr1:114023502-114928048 (+)
AKR/J	MGP_AKRJ_G0016332	protein coding gene	Chr1:117217429-118158487 (+)
BALB/cJ	MGP_BALBcJ_G0016328	protein coding gene	Chr1:114164483-115091795 (+)
C3H/HeJ	MGP_C3HHeJ_G0016155	protein coding gene	Chr1:117629337-118583145 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016787	protein coding gene	Chr1:122705128-123670455 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014505	protein coding gene	Chr1:107759017-108651350 (+)
CAST/EiJ	MGP_CASTEiJ_G0015738	protein coding gene	Chr1:116618419-117575982 (+)
CBA/J	MGP_CBAJ_G0016127	protein coding gene	Chr1:126952201-127963385 (+)
DBA/2J	MGP_DBA2J_G0016234	protein coding gene	Chr1:113057185-113961706 (+)
FVB/NJ	MGP_FVBNJ_G0016233	protein coding gene	Chr1:111822132-112720669 (+)
LP/J	MGP_LPJ_G0016307	protein coding gene	Chr1:119580648-120537878 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016260	protein coding gene	Chr1:132777761-133839603 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016825	protein coding gene	Chr1:117150946-118084347 (+)
PWK/PhJ	MGP_PWKPhJ_G0015524	protein coding gene	Chr1:112077882-113007766 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015312	protein coding gene	Chr1:115654495-116603495 (+)
WSB/EiJ	MGP_WSBEiJ_G0015800	protein coding gene	Chr1:117053350-117976658 (+)

Human Ortholog

CNTNAP5, contactin associated protein family member 5

Vertebrate Orthologs

6

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CNTNAP5, contactin associated protein family member 5
Synonyms

caspr5
Links

HGNC:18748

NCBI Gene ID: 129684

neXtProt AC: NX_Q8WYK1

UniProt: Q8WYK1
Chr Location

2q14.3; chr2:124025287-124921219 (+) GRCh38

MGI Vertebrate Homology

Cntnap5a stringent orthology
1 human;1 mouse;2 rat;3 zebrafish
HCOP

vertebrate homology predictions: CNTNAP5
Gene Tree

Cntnap5a

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Endonuclease-mediated

3
Gene trapped

2
Radiation induced

1
Genomic Mutations

3 involving Cntnap5a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

83 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

6
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

717
Tissues

6
cDNA Data

1
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

GEISHA CNTNAP5

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All Sequences

33
RefSeq

6
UniProt

2
CCDS

CCDS35689.1

Ensembl

ENSMUSG00000070695 (Evidence)
NCBI Gene

636808

			Length	Strain/Species	Flank
genomic	ENSMUSG00000070695	Ensembl Gene Model \| MGI Sequence Detail	902568	C57BL/6J	± kb
transcript	ENSMUST00000043725	Ensembl \| MGI Sequence Detail	10945	Not Applicable
polypeptide	ENSMUSP00000035732	Ensembl \| MGI Sequence Detail	1304	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000006195 contactin-associated protein like 5-1

(term hierarchy)
InterPro Domains

IPR001969 Aspartic peptidase, active site

IPR000421 Coagulation factor 5/8 C-terminal domain

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR000742 EGF-like domain

IPR002181 Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain

IPR036056 Fibrinogen-like, C-terminal

IPR008979 Galactose-binding-like domain superfamily

IPR001791 Laminin G domain

IPR050372 Neurexin-related cell adhesion and synaptic protein
GlyGen

Q0V8T9 9 sites, 6 N-linked glycans (5 sites), 1 O-linked glycan (1 site)

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All nucleic 4

cDNA 1

Primer pair 1

Other 2

Microarray probesets 1

Summaries

All 23

Developmental Gene Expression 1

Gene Ontology 4

Phenotypes 9
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cntnap5a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8354	Chr1:115612457-115612474 (+)	-20 bp
Tssr178	Chr1:115612684-115612688 (+)	200 bp
Tssr8355	Chr1:115754052-115754057 (+)	141,569 bp
Tssr8356	Chr1:115851707-115851713 (+)	239,224 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24