Usp17le MGI Mouse Gene Detail - MGI:107697 - ubiquitin specific peptidase 17-like E

Symbol

Usp17le
Name

ubiquitin specific peptidase 17-like E
Synonyms

Dub3, Gm6596

Feature Type

protein coding gene
IDs

MGI:107697
NCBI Gene: 625530
Alliance

gene page

Sequence Map

Chr7:104417256-104426677 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 55.69 cM
Mapping Data

2 experiments

SNPs within 2kb

448 from dbSNP Build 142
Strain Annotations

16
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107697	protein coding gene	Chr7:104417168-104426677 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032657	protein coding gene	Chr7:106554081-106555875 (+)
A/J	MGP_AJ_G0032704	protein coding gene	Chr7:105216382-105219864 (+)
AKR/J	MGP_AKRJ_G0032637	protein coding gene	Chr7:107783391-107787127 (-)
BALB/cJ	MGP_BALBcJ_G0032712	protein coding gene	Chr7:104796783-104799159 (-)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0033214	protein coding gene	Chr7:112183685-112185212 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030204	protein coding gene	Chr7:107276477-107279578 (+)
CAST/EiJ	MGP_CASTEiJ_G0031753	protein coding gene	Chr7:99755336-99759212 (-)
CBA/J	MGP_CBAJ_G0032396	protein coding gene	Chr7:115927652-115930348 (-)
DBA/2J	MGP_DBA2J_G0032547	protein coding gene	Chr7:103512537-103515879 (+)
FVB/NJ	MGP_FVBNJ_G0032499	protein coding gene	Chr7:103139552-103241649 (-)
LP/J	MGP_LPJ_G0032638	protein coding gene	Chr7:109245026-109246392 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032533	protein coding gene	Chr7:117417114-117418687 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033236	protein coding gene	Chr7:106924912-106926491 (-)
PWK/PhJ	MGP_PWKPhJ_G0031395	protein coding gene	Chr7:95012094-95013860 (-)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0031867	protein coding gene	Chr7:107603308-107613254 (-)

Human Ortholog

USP17L1, ubiquitin specific peptidase 17 like family member 1

Vertebrate Orthologs

29

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

USP17L1, ubiquitin specific peptidase 17 like family member 1
Synonyms

USP17L1P
Links

HGNC:37182

NCBI Gene ID: 401447

neXtProt AC: NX_Q7RTZ2

UniProt: Q7RTZ2
Chr Location

8p23.1; chr8:7332387-7333979 (+) GRCh38

Human Ortholog

USP17L10, ubiquitin specific peptidase 17 like family member 10
Links

HGNC:44438

NCBI Gene ID: 100287144

neXtProt AC: NX_C9JJH3

UniProt: C9JJH3
Chr Location

chr4:9210657-9212249 (+) GRCh38

Human Ortholog

USP17L11, ubiquitin specific peptidase 17 like family member 11
Links

HGNC:44439

NCBI Gene ID: 100287178

neXtProt AC: NX_C9JVI0

UniProt: C9JVI0
Chr Location

chr4:9215405-9216997 (+) GRCh38

Human Ortholog

USP17L12, ubiquitin specific peptidase 17 like family member 12
Links

HGNC:44440

NCBI Gene ID: 100287205

neXtProt AC: NX_C9JPN9

UniProt: C9JPN9
Chr Location

chr4:9220152-9221744 (+) GRCh38

Human Ortholog

USP17L13, ubiquitin specific peptidase 17 like family member 13
Links

HGNC:44441

NCBI Gene ID: 100287238

neXtProt AC: NX_C9JLJ4

UniProt: C9JLJ4
Chr Location

chr4:9224896-9226488 (+) GRCh38

Human Ortholog

USP17L15, ubiquitin specific peptidase 17 like family member 15
Links

HGNC:44443

NCBI Gene ID: 100288520

UniProt: C9J2P7
Chr Location

chr4:9234385-9236046 (+) GRCh38

Human Ortholog

USP17L17, ubiquitin specific peptidase 17 like family member 17
Links

HGNC:44445

NCBI Gene ID: 100287327

neXtProt AC: NX_D6RBQ6

UniProt: D6RBQ6
Chr Location

chr4:9243879-9245471 (+) GRCh38

Human Ortholog

USP17L18, ubiquitin specific peptidase 17 like family member 18
Links

HGNC:44446

NCBI Gene ID: 100287364

neXtProt AC: NX_D6R9N7

UniProt: D6R9N7
Chr Location

chr4:9248630-9250222 (+) GRCh38

Human Ortholog

USP17L19, ubiquitin specific peptidase 17 like family member 19
Links

HGNC:44447

NCBI Gene ID: 100287404

neXtProt AC: NX_D6RCP7

UniProt: D6RCP7
Chr Location

chr4:9253378-9254970 (+) GRCh38

Human Ortholog

USP17L2, ubiquitin specific peptidase 17 like family member 2 (gene/pseudogene)
Synonyms

DUB-3, DUB3, USP17
Links

HGNC:34434

NCBI Gene ID: 377630

neXtProt AC: NX_Q6R6M4

UniProt: Q6R6M4
Chr Location

8p23.1; chr8:12136435-12138849 (-) GRCh38

Human Ortholog

USP17L20, ubiquitin specific peptidase 17 like family member 20
Links

HGNC:44448

NCBI Gene ID: 100287441

neXtProt AC: NX_D6RJB6

UniProt: D6RJB6
Chr Location

chr4:9258124-9259716 (+) GRCh38

Human Ortholog

USP17L21, ubiquitin specific peptidase 17 like family member 21
Links

HGNC:44449

NCBI Gene ID: 100287478

neXtProt AC: NX_D6R901

UniProt: D6R901
Chr Location

chr4:9262872-9264464 (+) GRCh38

Human Ortholog

USP17L22, ubiquitin specific peptidase 17 like family member 22
Links

HGNC:44450

NCBI Gene ID: 100287513

neXtProt AC: NX_D6RA61

UniProt: D6RA61
Chr Location

chr4:9267619-9269211 (+) GRCh38

Human Ortholog

USP17L23, ubiquitin specific peptidase 17 like family member 23
Links

HGNC:44451

NCBI Gene ID: 101241878

UniProt: D6RBM5
Chr Location

4p16.1; chr4:9272364-9272914 (+) GRCh38

Human Ortholog

USP17L24, ubiquitin specific peptidase 17 like family member 24
Synonyms

USP17L25, USP17L26, USP17L27, USP17L28, USP17L29, USP17L30
Links

HGNC:44453

NCBI Gene ID: 728369

neXtProt AC: NX_Q0WX57

UniProt: Q0WX57
Chr Location

4p16.1; chr4:9325165-9326757 (+) GRCh38

Human Ortholog

USP17L25, ubiquitin specific peptidase 17 like family member 25
Links

HGNC:44452

NCBI Gene ID: 728373

neXtProt AC: NX_Q0WX57
Chr Location

4p16.1; chr4:9329911-9331503 (+) GRCh38

Human Ortholog

USP17L26, ubiquitin specific peptidase 17 like family member 26
Links

HGNC:44454

NCBI Gene ID: 728379

neXtProt AC: NX_Q0WX57
Chr Location

4p16.1; chr4:9334658-9336250 (+) GRCh38

Human Ortholog

USP17L27, ubiquitin specific peptidase 17 like family member 27
Links

HGNC:44455

NCBI Gene ID: 728393

neXtProt AC: NX_Q0WX57
Chr Location

4p16.1; chr4:9344148-9345740 (+) GRCh38

Human Ortholog

USP17L28, ubiquitin specific peptidase 17 like family member 28
Links

HGNC:44456

NCBI Gene ID: 728400

neXtProt AC: NX_Q0WX57
Chr Location

4p16.1; chr4:9348893-9350485 (+) GRCh38

Human Ortholog

USP17L29, ubiquitin specific peptidase 17 like family member 29
Links

HGNC:44457

NCBI Gene ID: 728405

neXtProt AC: NX_Q0WX57
Chr Location

4p16.1; chr4:9353638-9355230 (+) GRCh38

Human Ortholog

USP17L3, ubiquitin specific peptidase 17 like family member 3
Synonyms

USP17B, USP17F
Links

HGNC:37175

NCBI Gene ID: 645836

neXtProt AC: NX_A6NCW0

UniProt: A6NCW0
Chr Location

8p23.1; chr8:7976393-7977985 (-) GRCh38

Human Ortholog

USP17L30, ubiquitin specific peptidase 17 like family member 30
Links

HGNC:44458

NCBI Gene ID: 728419

neXtProt AC: NX_Q0WX57
Chr Location

4p16.1; chr4:9363129-9364721 (+) GRCh38

Human Ortholog

USP17L4, ubiquitin specific peptidase 17 like family member 4
Links

HGNC:37176

NCBI Gene ID: 645402

neXtProt AC: NX_A6NCW7

UniProt: A6NCW7
Chr Location

8p23.1; chr8:7337115-7338707 (+) GRCh38

Human Ortholog

USP17L5, ubiquitin specific peptidase 17 like family member 5
Links

HGNC:37177

NCBI Gene ID: 728386

neXtProt AC: NX_A8MUK1

UniProt: A8MUK1
Chr Location

4p16.1; chr4:9339403-9340995 (+) GRCh38

Human Ortholog

USP17L6P, ubiquitin specific peptidase 17 like family member 6, pseudogene
Synonyms

DUB4, USP17L6, vDUB4
Links

HGNC:37179

NCBI Gene ID: 391622

UniProt: Q6QN14
Chr Location

4p16.1; chr4:9367874-9369070 (+) GRCh38

Human Ortholog

USP17L7, ubiquitin specific peptidase 17 like family member 7 (gene/pseudogene)
Links

HGNC:37180

NCBI Gene ID: 392197

neXtProt AC: NX_P0C7H9

UniProt: P0C7H9
Chr Location

8p23.1; chr8:12132417-12134099 (-) GRCh38

Human Ortholog

USP17L8, ubiquitin specific peptidase 17 like family member 8
Synonyms

USP17L10
Links

HGNC:37181

NCBI Gene ID: 392188

neXtProt AC: NX_P0C7I0

UniProt: P0C7I0
Chr Location

8p23.1; chr8:7971661-7973253 (-) GRCh38

MGI Vertebrate Homology

Usp17le stringent orthology
27 human;1 mouse;2 rat
HCOP

vertebrate homology predictions: USP17L1, USP17L10, USP17L11, USP17L12, USP17L13, USP17L15, USP17L17, USP17L18, USP17L19, USP17L2, USP17L20, USP17L21, USP17L22, USP17L23, USP17L24, USP17L25, USP17L26, USP17L27, USP17L28, USP17L29, USP17L3, USP17L30, USP17L4, USP17L5, USP17L6P, USP17L7, USP17L8
Gene Tree

Usp17le

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Phenotype Summary

9 phenotype references

All Mutations and Alleles

2
Chemically induced (other)

1
Radiation induced

1
Genomic Mutations

2 involving Usp17le
Incidental Mutations

APF
Find Mice (IMSR)

21 strains or lines available

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All GO Annotations

37
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

29
RefSeq

6
UniProt

2
CCDS

CCDS85368.1

Ensembl

ENSMUSG00000043073 (Evidence)
NCBI Gene

625530

			Length	Strain/Species	Flank
genomic	ENSMUSG00000043073	Ensembl Gene Model \| MGI Sequence Detail	9422	C57BL/6J	± kb
transcript	ENSMUST00000211384	Ensembl \| MGI Sequence Detail	1885	Not Applicable
polypeptide	ENSMUSP00000147776	Ensembl \| MGI Sequence Detail	540	Not Applicable

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UniProt

2 Sequences
EC

3.4.19.12
InterPro Domains

IPR038765 Papain-like cysteine peptidase superfamily

IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase

IPR050164 Ubiquitin carboxyl-terminal hydrolases

IPR018200 Ubiquitin specific protease, conserved site

IPR028889 Ubiquitin specific protease domain

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All nucleic 1

Genomic 1

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MGD-MRK-36273, MGI:3643640

Summaries

All 30

Gene Ontology 5

Phenotypes 9
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:206170 van der Laan S, et al., High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency. Mol Cell. 2013 Nov 7;52(3):366-79

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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