Aadacl2fm3 Gene Detail

Summary

• Symbol
  Aadacl2fm3
• Name
  AADACL2 family member 3
• Synonyms
  Gm8298

• Feature Type
  protein coding gene
• IDs
  MGI:3643798
  NCBI Gene: 666803
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr3:59768472-59784734 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 29.07 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  477 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3643798	protein coding gene	Chr3:59768472-59784734 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027249	protein coding gene	Chr3:58711775-58728588 (+)
A/J	MGP_AJ_G0027209	protein coding gene	Chr3:56977960-56994319 (+)
AKR/J	MGP_AKRJ_G0027179	protein coding gene	Chr3:58122047-58138333 (+)
BALB/cJ	MGP_BALBcJ_G0027222	protein coding gene	Chr3:56734227-56751128 (+)
C3H/HeJ	MGP_C3HHeJ_G0026965	protein coding gene	Chr3:58319839-58337280 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027668	protein coding gene	Chr3:60901085-60917405 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025022	protein coding gene	Chr3:53178056-53192837 (+)
CAST/EiJ	MGP_CASTEiJ_G0026417	protein coding gene	Chr3:58502133-58519241 (+)
CBA/J	MGP_CBAJ_G0026941	protein coding gene	Chr3:62936269-62952542 (+)
DBA/2J	MGP_DBA2J_G0027075	protein coding gene	Chr3:56440992-56457242 (+)
FVB/NJ	MGP_FVBNJ_G0027043	protein coding gene	Chr3:55363521-55379919 (+)
LP/J	MGP_LPJ_G0027187	protein coding gene	Chr3:59537199-59555526 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027061	protein coding gene	Chr3:67067716-67087430 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027726	protein coding gene	Chr3:58049512-58065770 (+)
PWK/PhJ	MGP_PWKPhJ_G0026149	protein coding gene	Chr3:56074620-56091330 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025962	protein coding gene	Chr3:57641950-57659816 (+)
WSB/EiJ	MGP_WSBEiJ_G0026491	protein coding gene	Chr3:58170765-58187852 (+)

Homology

• MGI Vertebrate Homology
  Aadacl2fm3 stringent orthology
  1 mouse;1 rat;1 zebrafish
  
• Protein SuperFamily
  Arylacetamide_deacetylase
• Gene Tree
  Aadacl2fm3
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotype references
  

• All Mutations and Alleles
  3
• Endonuclease-mediated
  2
• Radiation induced
  1
• Genomic Mutations
  1 involving Aadacl2fm3
• Incidental Mutations
  APF
• Find Mice (IMSR)
  21 strains or lines available

Gene Ontology
(GO)
Classifications

Expression

• Assay Results
  706

Tissue x Stage Matrix

• Other Mouse Links
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  26
• RefSeq
  2
• UniProt
  1
• CCDS
  CCDS57214.1

• Ensembl
  ENSMUSG00000095522 (Evidence)
• NCBI Gene
  666803

Representative Sequences			Length	Strain/Species
genomic	666803	NCBI Gene Model | MGI Sequence Detail	16263	C57BL/6J
transcript	NM_001243003	RefSeq | MGI Sequence Detail	1206	C57BL/6
polypeptide	NP_001229932	RefSeq | MGI Sequence Detail	401	C57BL/6

Protein
Information

• UniProt
  1 Sequence
• EC
  3.1.1.71
• InterPro Domains
  IPR029058 Alpha/Beta hydrolase fold
  IPR013094 Alpha/beta hydrolase fold-3
  IPR017157 Arylacetamide deacetylase
  IPR050300 'GDXG' lipolytic enzyme
  IPR033140 Lipase, GDXG, putative serine active site

Other
Accession IDs

MGI:6330753

References

• Summaries
  All 10

  Diseases 1

  Phenotypes 3
• Earliest
  J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
• Latest
  J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426