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Ms4a4a Gene Detail
Summary
  • Symbol
    Ms4a4a
  • Name
    membrane-spanning 4-domains, subfamily A, member 4A
  • Synonyms
    EG666907
  • Feature Type
    protein coding gene
  • IDs
    MGI:3643932
    NCBI Gene: 666907
  • Member of
    Ms4ac cluster
  • Alliance
    gene page
  • Transcription Start Sites
    29 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:11352887-11370154 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 8.44 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    624 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3643932
 protein coding gene Chr19:11352827-11370682 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024877
 protein coding gene Chr19:8757273-8782621 (+)
A/J MGP_AJ_G0024845
 protein coding gene Chr19:8195380-8217976 (+)
AKR/J MGP_AKRJ_G0024820
 protein coding gene Chr19:8505632-8524316 (+)
BALB/cJ MGP_BALBcJ_G0024845
 protein coding gene Chr19:8231840-8249046 (+)
C3H/HeJ MGP_C3HHeJ_G0024611
 protein coding gene Chr19:8391025-8409612 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025293
 protein coding gene Chr19:9155879-9175282 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022720
 protein coding gene Chr19:8595777-8614062 (+)
CAST/EiJ MGP_CASTEiJ_G0024084
 protein coding gene Chr19:8025797-8051515 (+)
CBA/J MGP_CBAJ_G0024585
 protein coding gene Chr19:9215392-9242435 (+)
DBA/2J MGP_DBA2J_G0024712
 protein coding gene Chr19:8186309-8204764 (+)
FVB/NJ MGP_FVBNJ_G0024679
 protein coding gene Chr19:8212281-8231474 (+)
LP/J MGP_LPJ_G0024799
 protein coding gene Chr19:8724985-8742301 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024706
 protein coding gene Chr19:9099079-9118268 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025341
 protein coding gene Chr19:8533767-8551537 (+)
PWK/PhJ MGP_PWKPhJ_G0023828
 protein coding gene Chr19:7634121-7652744 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023634
 protein coding gene Chr19:7710440-7727755 (+)
WSB/EiJ MGP_WSBEiJ_G0024146
 protein coding gene Chr19:8428153-8446853 (+)



Homology
more
  • Human Ortholog
    MS4A4A, membrane spanning 4-domains A4A
  • Vertebrate Orthologs
    20
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MS4A4A, membrane spanning 4-domains A4A
  • Synonyms
    4SPAN1, CD20-L1, CD20L1, HDCME31P, MS4A4, MS4A7
  • Links
    NCBI Gene ID: 51338
    neXtProt AC: NX_Q96JQ5
    UniProt: Q96JQ5

  • Chr Location
    11q12.2; chr11:60185657-60318080 (+)  GRCh38
  • Human Ortholog
    MS4A4E, membrane spanning 4-domains A4E
  • Links
    NCBI Gene ID: 643680
    UniProt: Q96PG1

  • Chr Location
    11q12.2; chr11:60200270-60243137 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show abnormal macrophage physiology and impaired eosinophil infiltration during lung allergic inflammation induced by intranasal administration of house dust mite.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000101389 Ensembl Gene Model | MGI Sequence Detail 17268 C57BL/6J ±  kb
    transcript ENSMUST00000188995 Ensembl | MGI Sequence Detail 836 Not Applicable  
    polypeptide ENSMUSP00000140768 Ensembl | MGI Sequence Detail 236 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR007237 CD20-like family
      IPR030417 Membrane-spanning 4-domains subfamily A
    References
    more
    • Summaries
      All 16
      Gene Ontology 2
      Phenotypes 6
    • Earliest
      J:305894 Mattiola I, et al., The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell-mediated resistance to metastasis. Nat Immunol. 2019 Aug;20(8):1012-1022
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory