Zbtb42 MGI Mouse Gene Detail - MGI:3644133 - zinc finger and BTB domain containing 42

Symbol

Zbtb42
Name

zinc finger and BTB domain containing 42
Synonyms

Gm5188, simiRP58

Feature Type

protein coding gene
IDs

MGI:3644133
NCBI Gene: 382639
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr12:112645262-112649181 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 61.20 cM
Mapping Data

1 experiment

SNPs within 2kb

138 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3644133	protein coding gene	Chr12:112645042-112649181 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020157	protein coding gene	Chr12:115147713-115151084 (+)
A/J	MGP_AJ_G0020113	protein coding gene	Chr12:110708734-110712691 (+)
AKR/J	MGP_AKRJ_G0020088	protein coding gene	Chr12:113897877-113901832 (+)
BALB/cJ	MGP_BALBcJ_G0020098	protein coding gene	Chr12:111153059-111156980 (+)
C3H/HeJ	MGP_C3HHeJ_G0019900	protein coding gene	Chr12:114407417-114411372 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020543	protein coding gene	Chr12:118706066-118711910 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018157	protein coding gene	Chr12:107139411-107143378 (+)
CAST/EiJ	MGP_CASTEiJ_G0019440	protein coding gene	Chr12:109255005-109258962 (+)
CBA/J	MGP_CBAJ_G0019867	protein coding gene	Chr12:123242094-123246049 (+)
DBA/2J	MGP_DBA2J_G0019984	protein coding gene	Chr12:110187617-110191553 (+)
FVB/NJ	MGP_FVBNJ_G0019969	protein coding gene	Chr12:109013707-109017663 (+)
LP/J	MGP_LPJ_G0020058	protein coding gene	Chr12:114975058-114980123 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020007	protein coding gene	Chr12:126327382-126332709 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020572	protein coding gene	Chr12:113422750-113429551 (+)
PWK/PhJ	MGP_PWKPhJ_G0019202	protein coding gene	Chr12:104845911-104849982 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019006	protein coding gene	Chr12:107585325-107589247 (+)
WSB/EiJ	MGP_WSBEiJ_G0019500	protein coding gene	Chr12:114329702-114333660 (+)

Human Ortholog

ZBTB42, zinc finger and BTB domain containing 42

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ZBTB42, zinc finger and BTB domain containing 42
Synonyms

LCCS6, ZNF925
Links

HGNC:32550

NCBI Gene ID: 100128927

neXtProt AC: NX_B2RXF5

UniProt: B2RXF5
Chr Location

14q32.33; chr14:104800554-104804712 (+) GRCh38

MGI Vertebrate Homology

Zbtb42 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ZBTB42
Gene Tree

Zbtb42

Diseases

1 with human ZBTB42 associations

				Human Disease	Mouse Models
				lethal congenital contracture syndrome IDs lethal congenital contracture syndrome DOID:0060558 ICD10CM:Q68.8 OMIM:PS253310 ORDO:294965

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

1
Endonuclease-mediated

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

22
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

41
RefSeq

4
UniProt

3
CCDS

CCDS49190.1

Ensembl

ENSMUSG00000037638 (Evidence)
NCBI Gene

382639

			Length	Strain/Species	Flank
genomic	ENSMUSG00000037638	Ensembl Gene Model \| MGI Sequence Detail	3920	C57BL/6J	± kb
transcript	ENSMUST00000169593	Ensembl \| MGI Sequence Detail	3478	Not Applicable
polypeptide	ENSMUSP00000133152	Ensembl \| MGI Sequence Detail	420	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000017583 zinc finger and BTB domain-containing protein 42

(term hierarchy)
InterPro Domains

IPR000210 BTB/POZ domain

IPR011333 SKP1/BTB/POZ domain superfamily

IPR036236 Zinc finger C2H2 superfamily

IPR013087 Zinc finger C2H2-type

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All nucleic 22

cDNA 22

Microarray probesets 1

Summaries

All 24

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 3
Earliest

J:91257 Gray PA, et al., Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Zbtb42:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115392	Chr12:112645216-112645232 (+)	-38 bp
Tssr115393	Chr12:112645237-112645257 (+)	-15 bp
Tssr115394	Chr12:112645971-112645982 (+)	715 bp
Tssr115395	Chr12:112645990-112645995 (+)	731 bp
Tssr115396	Chr12:112645997-112646015 (+)	744 bp
Tssr115397	Chr12:112646024-112646033 (+)	767 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24