Ighv1-59 Gene Detail

Summary

• Symbol
  Ighv1-59
• Name
  immunoglobulin heavy variable V1-59

• Feature Type
  gene segment
• IDs
  MGI:3644474
  NCBI Gene: 432708
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Chr12:115298702-115299134 bp, - strand

  From Ensembl annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 12, 62.54 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  330 from dbSNP Build 142
• Strain Annotations
  4

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3644474	gene segment	Chr12:115298677-115299134 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0000089	gene segment	Chr12:118127364-118420338 (-)
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0000121	gene segment	Chr12:121758497-121759031 (-)
CAROLI/EiJ	no annotation
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0000111	gene segment	Chr12:116662544-116662976 (-)
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Homology

• Human Ortholog
  IGHV1-18, immunoglobulin heavy variable 1-18

• Vertebrate Orthologs
  16

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  IGHV1-18, immunoglobulin heavy variable 1-18
  
• Synonyms
  IGHV118
• Links
  HGNC:5549

  NCBI Gene ID: 28468

  UniProt: A0A0C4DH31

  
  
• Chr Location
  14q32.33; chr14:106184899-106185394 (-)  GRCh38

---

• Human Ortholog
  IGHV1-2, immunoglobulin heavy variable 1-2
  
• Synonyms
  IGHV12, V35
• Links
  HGNC:5550

  NCBI Gene ID: 28474

  
  
• Chr Location
  14q32.33; chr14:105986582-105987083 (-)  GRCh38

---

• Human Ortholog
  IGHV1-24, immunoglobulin heavy variable 1-24
  
• Synonyms
  IGHV124, VH
• Links
  HGNC:5551

  NCBI Gene ID: 28467

  UniProt: A0A0C4DH33

  
  
• Chr Location
  14q32.33; chr14:106276546-106277043 (-)  GRCh38

---

• Human Ortholog
  IGHV1-3, immunoglobulin heavy variable 1-3
  
• Synonyms
  IGHV13, VI-3B
• Links
  HGNC:5552

  NCBI Gene ID: 28473

  UniProt: A0A0C4DH29

  
  
• Chr Location
  14q32.33; chr14:106005095-106005574 (-)  GRCh38

---

• Human Ortholog
  IGHV1-38-4, immunoglobulin heavy variable 1-38-4 (non-functional)
  
• Synonyms
  IGHV1-C, IGHV1C
• Links
  HGNC:5560

  NCBI Gene ID: 28460

  UniProt: P0DTW3

  
  
• Chr Location
  14q32.33

---

• Human Ortholog
  IGHV1-45, immunoglobulin heavy variable 1-45
  
• Synonyms
  IGHV145, VH
• Links
  HGNC:5553

  NCBI Gene ID: 28466

  UniProt: A0A0A0MS14

  
  
• Chr Location
  14q32.33; chr14:106506996-106507491 (-)  GRCh38

---

• Human Ortholog
  IGHV1-46, immunoglobulin heavy variable 1-46
  
• Synonyms
  IGHV146
• Links
  HGNC:5554

  NCBI Gene ID: 28465

  
  
• Chr Location
  14q32.33; chr14:106511115-106511856 (-)  GRCh38

---

• Human Ortholog
  IGHV1-58, immunoglobulin heavy variable 1-58
  
• Synonyms
  IGHV158, VH
• Links
  HGNC:5555

  NCBI Gene ID: 28464

  UniProt: A0A0C4DH39

  
  
• Chr Location
  14q32.33; chr14:106622357-106622855 (-)  GRCh38

---

• Human Ortholog
  IGHV1-69, immunoglobulin heavy variable 1-69
  
• Synonyms
  IGHV169, IGHV1-E, IGHV1E
• Links
  HGNC:5558

  NCBI Gene ID: 28461

  UniProt: P01742

  
  
• Chr Location
  14q32.33; chr14:106714682-106715181 (-)  GRCh38

---

• Human Ortholog
  IGHV1-69-2, immunoglobulin heavy variable 1-69-2
  
• Synonyms
  IGHV1-F, IGHV1F
• Links
  HGNC:5562

  NCBI Gene ID: 28458

  UniProt: A0A0G2JMI3

  
  
• Chr Location
  14q32.33; chr14:106737110-106737547 (-)  GRCh38

---

• Human Ortholog
  IGHV1-69D, immunoglobulin heavy variable 1-69D
  
• Links
  HGNC:49601

  NCBI Gene ID: 102723169

  UniProt: A0A0B4J2H0

  
  
• Chr Location
  14q32.33; chr14:106762092-106762588 (-)  GRCh38

---

• Human Ortholog
  IGHV1OR15-1, immunoglobulin heavy variable 1/OR15-1 (non-functional)
  
• Synonyms
  IGHV1/OR15-1, IGHV1OR151
• Links
  HGNC:5563

  NCBI Gene ID: 388077

  
  
• Chr Location
  15q11.2; chr15:22160289-22160930 (-)  GRCh38

---

• Human Ortholog
  IGHV1OR15-9, immunoglobulin heavy variable 1/OR15-9 (non-functional)
  
• Synonyms
  IGHV1OR159, VSIG7
• Links
  HGNC:5569

  NCBI Gene ID: 390531

  
  
• Chr Location
  15q11.1; chr15:19964656-19965101 (-)  GRCh38

---

• Human Ortholog
  IGHV1OR21-1, immunoglobulin heavy variable 1/OR21-1 (non-functional)
  
• Links
  HGNC:38040

  NCBI Gene ID: 390530

  
  
• Chr Location
  21p11.2; chr21:10649390-10649835 (-)  GRCh38

---

• MGI Vertebrate Homology
  Ighv1-59 stringent orthology
  14 human;1 mouse;2 zebrafish
  
• HCOP
  vertebrate homology predictions: IGHV1-18, IGHV1-2, IGHV1-24, IGHV1-3, IGHV1-38-4, IGHV1-45, IGHV1-46, IGHV1-58, IGHV1-69, IGHV1-69-2, IGHV1-69D, IGHV1OR15-1, IGHV1OR15-9, IGHV1OR21-1
• Gene Tree
  Ighv1-59
  

Mutations,
Alleles, and
Phenotypes

• Incidental Mutations
  APF
• Find Mice (IMSR)
  4 strains or lines available

Expression

• Assay Results
  706

Tissue x Stage Matrix

• Other Mouse Links
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  10
• RefSeq
  1
• UniProt
  1

• Ensembl
  ENSMUSG00000095197 (Evidence)
• NCBI Gene
  432708

Representative Sequences			Length	Strain/Species
genomic	ENSMUSG00000095197	Ensembl Gene Model | MGI Sequence Detail	433	C57BL/6J
transcript	ENSMUST00000195359	Ensembl | MGI Sequence Detail	351	Not Applicable
polypeptide	ENSMUSP00000141949	Ensembl | MGI Sequence Detail	117	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR050199 Immunoglobulin Heavy Variable
  IPR007110 Immunoglobulin-like domain
  IPR036179 Immunoglobulin-like domain superfamily
  IPR013783 Immunoglobulin-like fold
  IPR013106 Immunoglobulin V-set domain

References

• Summaries
  All 6
• Earliest
  J:164272 Giudicelli V, et al., IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D256-61