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Rad51ap2 Gene Detail
Summary
  • Symbol
    Rad51ap2
  • Name
    RAD51 associated protein 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:3644580
    NCBI Gene: 209550
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:11506080-11512929 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 5.58 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    217 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3644580
 protein coding gene Chr12:11506024-11513154 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019601
 protein coding gene Chr12:8666371-8673218 (+)
A/J MGP_AJ_G0019568
 protein coding gene Chr12:8345795-8353217 (+)
AKR/J MGP_AKRJ_G0019538
 protein coding gene Chr12:8883326-8896770 (+)
BALB/cJ MGP_BALBcJ_G0019543
 protein coding gene Chr12:8534878-8541725 (+)
C3H/HeJ MGP_C3HHeJ_G0019349
 protein coding gene Chr12:8682621-8690195 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019992
 protein coding gene Chr12:8953009-8960700 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017619
 protein coding gene Chr12:8111709-8118280 (+)
CAST/EiJ MGP_CASTEiJ_G0018905
 protein coding gene Chr12:8653437-8661293 (+)
CBA/J MGP_CBAJ_G0019320
 protein coding gene Chr12:9577751-9584604 (+)
DBA/2J MGP_DBA2J_G0019433
 protein coding gene Chr12:8309941-8316819 (+)
FVB/NJ MGP_FVBNJ_G0019424
 protein coding gene Chr12:8260148-8266872 (+)
LP/J MGP_LPJ_G0019504
 protein coding gene Chr12:8731543-8738440 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019457
 protein coding gene Chr12:9393273-9418118 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020031
 protein coding gene Chr12:8558615-8566342 (+)
PWK/PhJ MGP_PWKPhJ_G0018671
 protein coding gene Chr12:8409717-8416692 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018461
 protein coding gene Chr12:8654739-8662625 (+)
WSB/EiJ MGP_WSBEiJ_G0018956
 protein coding gene Chr12:8638689-8645939 (+)



Homology
more
  • Human Ortholog
    RAD51AP2, RAD51 associated protein 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RAD51AP2, RAD51 associated protein 2
  • Links
    NCBI Gene ID: 729475
    neXtProt AC: NX_Q09MP3
    UniProt: Q09MP3

  • Chr Location
    2p24.2; chr2:17510579-17537859 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a truncated allele exhibit decreased testis weight, oligospermia, arrested male meiosis, and abnormal increased frequency of XY dissociation in meiotic metaphase I spermatocytes with reduced crossover and compromised double-strand break repair in the pseudoautosomal region.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    2
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000086022 Ensembl Gene Model | MGI Sequence Detail 6850 C57BL/6J ±  kb
    transcript ENSMUST00000124065 Ensembl | MGI Sequence Detail 3175 Not Applicable  
    polypeptide ENSMUSP00000128854 Ensembl | MGI Sequence Detail 976 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR053355 RAD51-associated protein
      IPR031419 RAD51 interacting motif
    References
    more
    • Summaries
      All 12
      Gene Ontology 2
      Phenotypes 3
    • Earliest
      J:321708 Ma H, et al., RAD51AP2 is required for efficient meiotic recombination between X and Y chromosomes. Sci Adv. 2022 Jan 14;8(2):eabk1789
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory