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Prlh Gene Detail
Summary
  • Symbol
    Prlh
  • Name
    prolactin releasing hormone
  • Synonyms
    EG623503
  • Feature Type
    protein coding gene
  • IDs
    MGI:3644668
    NCBI Gene: 623503
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr1:90880830-90881749 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 45.81 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    154 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3644668
 protein coding gene Chr1:90879545-90881848 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016298
 protein coding gene Chr1:92482348-92483267 (+)
A/J MGP_AJ_G0016279
 protein coding gene Chr1:89154122-89155041 (+)
AKR/J MGP_AKRJ_G0016240
 protein coding gene Chr1:91810244-91811163 (+)
BALB/cJ MGP_BALBcJ_G0016235
 protein coding gene Chr1:89331646-89332565 (+)
C3H/HeJ MGP_C3HHeJ_G0016064
 protein coding gene Chr1:92009346-92010265 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016694
 protein coding gene Chr1:96040364-96041283 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014412
 protein coding gene Chr1:83422349-83423276 (+)
CAST/EiJ MGP_CASTEiJ_G0015649
 protein coding gene Chr1:91343808-91344727 (+)
CBA/J MGP_CBAJ_G0016040
 protein coding gene Chr1:99106563-99107482 (+)
DBA/2J MGP_DBA2J_G0016143
 protein coding gene Chr1:88386756-88387675 (+)
FVB/NJ MGP_FVBNJ_G0016142
 protein coding gene Chr1:87406506-87407425 (+)
LP/J MGP_LPJ_G0016214
 protein coding gene Chr1:93648575-93649494 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016167
 protein coding gene Chr1:102358486-102359405 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016734
 protein coding gene Chr1:91831325-91832244 (+)
PWK/PhJ MGP_PWKPhJ_G0015433
 protein coding gene Chr1:87794441-87795586 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015216
 protein coding gene Chr1:90750372-90751304 (+)
WSB/EiJ MGP_WSBEiJ_G0015707
 protein coding gene Chr1:91619525-91620444 (+)



Homology
more
  • Human Ortholog
    PRLH, prolactin releasing hormone
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRLH, prolactin releasing hormone
  • Synonyms
    PRH, PRRP
  • Links
    NCBI Gene ID: 51052
    neXtProt AC: NX_P81277
    UniProt: P81277

  • Chr Location
    2q37.3; chr2:237566574-237567175 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Prlh mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in polyphagia; late-onset obesity and adiposity; increase in circulating insulin, leptin, and triglyceride levels; impaired glucose tolerance and insulin resistance; and attenuated responses to the anorexigenic signals cholecystokinin and leptin.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000090550 Ensembl Gene Model | MGI Sequence Detail 920 C57BL/6J ±  kb
    transcript ENSMUST00000166281 Ensembl | MGI Sequence Detail 276 Not Applicable  
    polypeptide ENSMUSP00000130768 Ensembl | MGI Sequence Detail 86 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR026194 Prolactin-releasing peptide
    Molecular
    Reagents
    less

    • Microarray probesets 1
    References
    more
    • Summaries
      All 23
      Diseases 1
      Gene Ontology 4
      Phenotypes 11
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:309169 Cheng W, et al., NTS Prlh overcomes orexigenic stimuli and ameliorates dietary and genetic forms of obesity. Nat Commun. 2021 Aug 30;12(1):5175
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory