Csta3 MGI Mouse Gene Detail - MGI:3644688 - cystatin A family member 3

Symbol

Csta3
Name

cystatin A family member 3
Synonyms

Gm5416

Feature Type

protein coding gene
IDs

MGI:3644688
NCBI Gene: 408196
Alliance

gene page

Sequence Map

Chr16:36030773-36038158 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 25.43 cM
Mapping Data

1 experiment

SNPs within 2kb

221 from dbSNP Build 142
Strain Annotations

16

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3644688	protein coding gene	Chr16:36030773-36038158 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022784	protein coding gene	Chr16:34608886-34616295 (+)
A/J	MGP_AJ_G0022749	protein coding gene	Chr16:32928858-32936151 (+)
AKR/J	MGP_AKRJ_G0022721	protein coding gene	Chr16:34079064-34089462 (+)
BALB/cJ	MGP_BALBcJ_G0022749	protein coding gene	Chr16:33060940-33068425 (+)
C3H/HeJ	MGP_C3HHeJ_G0022515	protein coding gene	Chr16:34251230-34260832 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0023196	protein coding gene	Chr16:35365697-35386424 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0022041	protein coding gene	Chr16:34414118-34426108 (+)
CBA/J	MGP_CBAJ_G0022483	protein coding gene	Chr16:36858337-36879148 (+)
DBA/2J	MGP_DBA2J_G0022618	protein coding gene	Chr16:32759070-32766324 (+)
FVB/NJ	MGP_FVBNJ_G0022593	protein coding gene	Chr16:32759010-32766843 (+)
LP/J	MGP_LPJ_G0022684	protein coding gene	Chr16:34339791-34347660 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022613	protein coding gene	Chr16:36046536-36054851 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023211	protein coding gene	Chr16:34146964-34160721 (+)
PWK/PhJ	MGP_PWKPhJ_G0021782	protein coding gene	Chr16:33248024-33253593 (-)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0022087	protein coding gene	Chr16:34066850-34074211 (+)

Human Ortholog

CSTA, cystatin A

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CSTA, cystatin A
Synonyms

AREI, PSS4, STF1, STFA
Links

HGNC:2481

NCBI Gene ID: 1475

neXtProt AC: NX_P01040

UniProt: P01040
Chr Location

3q21.1; chr3:122325248-122341969 (+) GRCh38

MGI Vertebrate Homology

Csta3 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: CSTA
Gene Tree

Csta3

Diseases

1 with human CSTA associations

				Human Disease	Mouse Models
				peeling skin syndrome 4 IDs peeling skin syndrome 4 DOID:0070523 MESH:C564309 OMIM:607936

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotype references

All Mutations and Alleles

5
Endonuclease-mediated

1
Gene trapped

2
Targeted

2
Find Mice (IMSR)

6 strains or lines available

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All GO Annotations

15
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

1

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas

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All Sequences

26
RefSeq

2
UniProt

2
CCDS

CCDS37329.1

Ensembl

ENSMUSG00000094733 (Evidence)
NCBI Gene

408196

			Length	Strain/Species	Flank
genomic	408196	NCBI Gene Model \| MGI Sequence Detail	7386	C57BL/6J	± kb
transcript	NM_001082542	RefSeq \| MGI Sequence Detail	294	C57BL/6
polypeptide	NP_001076011	RefSeq \| MGI Sequence Detail	97	C57BL/6

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UniProt

2 Sequences
InterPro Domains

IPR000010 Cystatin domain

IPR046350 Cystatin superfamily

IPR001713 Proteinase inhibitor I25A, stefin

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All nucleic 1

cDNA 1

Microarray probesets 1

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MGI:6274746

Summaries

All 15

Gene Ontology 2

Phenotypes 5
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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