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H2ab3 Gene Detail
Summary
  • Symbol
    H2ab3
  • Name
    H2A.B variant histone 3
  • Synonyms
    EG624957, H2A.Bbd3, H2afb3, H2afb3-ps
  • Feature Type
    protein coding gene
  • IDs
    MGI:3644875
    NCBI Gene: 624957
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:119222445-119222792 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 49.58 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    88 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3644875
 protein coding gene ChrX:119222279-119222923 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036042
 protein coding gene ChrX:113471457-113471804 (+)
A/J MGP_AJ_G0036027
 protein coding gene ChrX:116801634-116801981 (-)
AKR/J MGP_AKRJ_G0035941
 protein coding gene ChrX:116834970-116835317 (+)
BALB/cJ MGP_BALBcJ_G0036019
 protein coding gene ChrX:115280254-115280601 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0036539
 protein coding gene ChrX:116817253-116817600 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0035008
 protein coding gene ChrX:97914445-97914792 (-)
CBA/J MGP_CBAJ_G0035695
 protein coding gene ChrX:120541807-120542154 (+)
DBA/2J MGP_DBA2J_G0035848
 protein coding gene ChrX:112466248-112466595 (+)
FVB/NJ MGP_FVBNJ_G0035788
 protein coding gene ChrX:111389392-111389739 (+)
LP/J MGP_LPJ_G0035941
 protein coding gene ChrX:114405787-114406134 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035824
 protein coding gene ChrX:130596446-130596793 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036570
 protein coding gene ChrX:116703774-116704121 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0035148
 protein coding gene ChrX:115331484-115331831 (-)



Homology
more
  • Human Ortholog
    H2AB1, H2A.B variant histone 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    H2AB1, H2A.B variant histone 1
  • Synonyms
    H2A.B, H2A.B.2, H2A.Bbd, H2AFB1
  • Links
    NCBI Gene ID: 474382
    neXtProt AC: NX_P0C5Y9
    UniProt: P0C5Y9

  • Chr Location
    Xq28; chrX:154884972-154885558 (+)  GRCh38
  • Human Ortholog
    H2AB2, H2A.B variant histone 2
  • Synonyms
    H2A.B.1, H2AB3, H2A.Bbd, H2AFB2
  • Links
    NCBI Gene ID: 474381
    neXtProt AC: NX_P0C5Z0
    UniProt: P0C5Z0

  • Chr Location
    Xq28; chrX:155380709-155381299 (+)  GRCh38
  • Human Ortholog
    H2AB3, H2A.B variant histone 3
  • Synonyms
    H2A.B.1, H2AB2, H2ABBD, H2AFB, H2AFB3
  • Links
    NCBI Gene ID: 83740
    neXtProt AC: NX_P0C5Z0
    UniProt: P0C5Z0

  • Chr Location
    Xq28; chrX:155459415-155460005 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotypes from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice hemizygous for knock-out alleles of H2afb1, H2afb2 and H2afb3 exhibit reduced fertility, teratozoospermia, oligozoospermia and clogged seminiferous tubules.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000083616 Ensembl Gene Model | MGI Sequence Detail 348 C57BL/6J ±  kb
    transcript ENSMUST00000122050 Ensembl | MGI Sequence Detail 348 Not Applicable  
    polypeptide ENSMUSP00000138211 Ensembl | MGI Sequence Detail 115 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 1
      cDNA 1
    Other
    Accession IDs
    less
    MGI:6358826
    References
    more
    • Summaries
      All 15
      Gene Ontology 2
      Phenotypes 4
    • Earliest
      J:173007 Ishibashi T, et al., H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis. Nucleic Acids Res. 2010 Apr;38(6):1780-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory