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H2ab2 Gene Detail
Summary
  • Symbol
    H2ab2
  • Name
    H2A.B variant histone 2
  • Synonyms
    EG624153, H2A.Bbd4, H2afb2, H2afb2-ps
  • Feature Type
    protein coding gene
  • IDs
    MGI:3644980
    NCBI Gene: 624153
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    ChrX:115590875-115591222 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 49.55 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    147 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3644980
 protein coding gene ChrX:115590875-115591222 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0036023
 protein coding gene ChrX:113221101-113221448 (+)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0036015
 protein coding gene ChrX:111727326-111727673 (+)
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0033370
 protein coding gene ChrX:112963876-112964213 (-)
CAST/EiJ MGP_CASTEiJ_G0035006
 protein coding gene ChrX:97632437-97632784 (+)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0035791
 protein coding gene ChrX:111878339-111878686 (+)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0035820
 protein coding gene ChrX:126305631-126305978 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036566
 protein coding gene ChrX:113005115-113005462 (+)
PWK/PhJ MGP_PWKPhJ_G0034699
 protein coding gene ChrX:94533301-94533647 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034532
 protein coding gene ChrX:98696648-98696995 (+)
WSB/EiJ MGP_WSBEiJ_G0035144
 protein coding gene ChrX:111706812-111707159 (+)



Homology
more
  • Human Ortholog
    H2AB1, H2A.B variant histone 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    H2AB1, H2A.B variant histone 1
  • Synonyms
    H2A.B, H2A.B.2, H2A.Bbd, H2AFB1
  • Links
    NCBI Gene ID: 474382
    neXtProt AC: NX_P0C5Y9
    UniProt: P0C5Y9

  • Chr Location
    Xq28; chrX:154884972-154885558 (+)  GRCh38
  • Human Ortholog
    H2AB2, H2A.B variant histone 2
  • Synonyms
    H2A.B.1, H2AB3, H2A.Bbd, H2AFB2
  • Links
    NCBI Gene ID: 474381
    neXtProt AC: NX_P0C5Z0
    UniProt: P0C5Z0

  • Chr Location
    Xq28; chrX:155380709-155381299 (+)  GRCh38
  • Human Ortholog
    H2AB3, H2A.B variant histone 3
  • Synonyms
    H2A.B.1, H2AB2, H2ABBD, H2AFB, H2AFB3
  • Links
    NCBI Gene ID: 83740
    neXtProt AC: NX_P0C5Z0
    UniProt: P0C5Z0

  • Chr Location
    Xq28; chrX:155459415-155460005 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from multigenic genotypes
    1 phenotype reference
Male mice hemizygous for knock-out alleles of H2afb1, H2afb2 and H2afb3 exhibit reduced fertility, teratozoospermia, oligozoospermia and clogged seminiferous tubules.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    8
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 624153 NCBI Gene Model | MGI Sequence Detail 348 C57BL/6J ±  kb
transcript NM_001281530 RefSeq | MGI Sequence Detail 348 C57BL/6  
polypeptide NP_001268459 RefSeq | MGI Sequence Detail 115 C57BL/6  
For the selected sequence
Protein
Information
less
Other
Accession IDs
less
MGI:6358825
References
more
  • Summaries
    All 11
    Gene Ontology 2
    Phenotypes 1
  • Earliest
    J:173007 Ishibashi T, et al., H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesis. Nucleic Acids Res. 2010 Apr;38(6):1780-9
  • Latest
    J:300161 Molaro A, et al., Biparental contributions of the H2A.B histone variant control embryonic development in mice. PLoS Biol. 2020 Dec;18(12):e3001001
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory