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Lipt1 Gene Detail
Summary
  • Symbol
    Lipt1
  • Name
    lipoyltransferase 1
  • Synonyms
    EG623661
  • Feature Type
    protein coding gene
  • IDs
    MGI:3645211
    NCBI Gene: 623661
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:37910819-37915309 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 16.13 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    181 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3645211
 protein coding gene Chr1:37910819-37915309 (+)
129S1/SvImJ MGP_129S1SvImJ_G0015942
 protein coding gene Chr1:36520208-36524699 (+)
A/J MGP_AJ_G0015926
 protein coding gene Chr1:35513553-35518043 (+)
AKR/J MGP_AKRJ_G0015881
 protein coding gene Chr1:36004536-36009026 (+)
BALB/cJ MGP_BALBcJ_G0015880
 protein coding gene Chr1:35165251-35169741 (+)
C3H/HeJ MGP_C3HHeJ_G0015713
 protein coding gene Chr1:36230259-36234749 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016333
 protein coding gene Chr1:38105613-38110103 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014055
 protein coding gene Chr1:32505039-32509546 (+)
CAST/EiJ MGP_CASTEiJ_G0015294
 protein coding gene Chr1:36090721-36095211 (+)
CBA/J MGP_CBAJ_G0015685
 protein coding gene Chr1:39161343-39165833 (+)
DBA/2J MGP_DBA2J_G0015786
 protein coding gene Chr1:34819448-34823939 (+)
FVB/NJ MGP_FVBNJ_G0015788
 protein coding gene Chr1:34350636-34355126 (+)
LP/J MGP_LPJ_G0015856
 protein coding gene Chr1:36868508-36872998 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015808
 protein coding gene Chr1:41314706-41319196 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016380
 protein coding gene Chr1:36073343-36077833 (+)
PWK/PhJ MGP_PWKPhJ_G0015077
 protein coding gene Chr1:34591499-34596038 (+)
SPRET/EiJ MGP_SPRETEiJ_G0014859
 protein coding gene Chr1:36021366-36025856 (+)
WSB/EiJ MGP_WSBEiJ_G0015356
 protein coding gene Chr1:36030382-36034870 (+)



Homology
more
  • Human Ortholog
    LIPT1, lipoyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIPT1, lipoyltransferase 1
  • Synonyms
    LIPT1D
  • Links
    NCBI Gene ID: 51601
    neXtProt AC: NX_Q9Y234
    UniProt: Q9Y234

  • Chr Location
    2q11.2; chr2:99154955-99163157 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit pallor and decreased size at E10.5 and die prior to E11.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    715
  • Tissues
    1
  • cDNA Data
    14
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 623661 NCBI Gene Model | MGI Sequence Detail 4491 C57BL/6J ±  kb
    transcript NM_001377033 RefSeq | MGI Sequence Detail 4610 C57BL/6  
    polypeptide Q8VCM4 UniProt | EBI | MGI Sequence Detail 373 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000009842 lipoyl amidotransferase LIPT1, mitochondrial
      (term hierarchy)
    • EC
      2.3.1.-, 2.3.1.200
    • InterPro Domains
      IPR004143 Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL), catalytic domain
      IPR045864 Class II Aminoacyl-tRNA synthetase/Biotinyl protein ligase (BPL) and lipoyl protein ligase (LPL)
      IPR004562 Lipoyltransferase/lipoate-protein ligase
    Molecular
    Reagents
    less
    • All nucleic 14
      cDNA 14

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 14
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory