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Rgs21 Gene Detail
Summary
  • Symbol
    Rgs21
  • Name
    regulator of G-protein signalling 21
  • Synonyms
    EG624910
  • Feature Type
    protein coding gene
  • IDs
    MGI:3645243
    NCBI Gene: 624910
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr1:144392388-144443185 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 62.66 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1309 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3645243
 protein coding gene Chr1:144392386-144443405 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016568
 protein coding gene Chr1:148889195-148946559 (-)
A/J MGP_AJ_G0016551
 protein coding gene Chr1:142934040-142986653 (-)
AKR/J MGP_AKRJ_G0016516
 protein coding gene Chr1:147335665-147386580 (-)
BALB/cJ MGP_BALBcJ_G0016511
 protein coding gene Chr1:143374818-143425879 (-)
C3H/HeJ MGP_C3HHeJ_G0016336
 protein coding gene Chr1:147447487-147499341 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016972
 protein coding gene Chr1:153898553-153957368 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014681
 protein coding gene Chr1:135711938-135763327 (-)
CAST/EiJ MGP_CASTEiJ_G0015915
 protein coding gene Chr1:146852126-146906020 (-)
CBA/J MGP_CBAJ_G0016310
 protein coding gene Chr1:159366053-159421563 (-)
DBA/2J MGP_DBA2J_G0016416
 protein coding gene Chr1:142042894-142094413 (-)
FVB/NJ MGP_FVBNJ_G0016414
 protein coding gene Chr1:140505372-140559067 (-)
LP/J MGP_LPJ_G0016487
 protein coding gene Chr1:149895954-149949513 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016440
 protein coding gene Chr1:165802140-165876709 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017008
 protein coding gene Chr1:147068124-147121599 (-)
PWK/PhJ MGP_PWKPhJ_G0015701
 protein coding gene Chr1:140929214-140984821 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015488
 protein coding gene Chr1:145851625-145901388 (-)
WSB/EiJ MGP_WSBEiJ_G0015978
 protein coding gene Chr1:147110154-147166657 (-)



Homology
more
  • Human Ortholog
    RGS21, regulator of G protein signaling 21
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RGS21, regulator of G protein signaling 21
  • Links
    NCBI Gene ID: 431704
    neXtProt AC: NX_Q2M5E4
    UniProt: Q2M5E4

  • Chr Location
    1q31.2; chr1:192316992-192367285 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice show reduced aversion to bitter taste and reduced preference towards sweeteners, umami taste, and salty taste.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    1
Molecular Function

Biological Process

Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 624910 NCBI Gene Model | MGI Sequence Detail 50798 C57BL/6J ±  kb
    transcript NM_001290269 RefSeq | MGI Sequence Detail 2721 C57BL/6  
    polypeptide NP_001277198 RefSeq | MGI Sequence Detail 152 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less

    • Microarray probesets 1
    References
    more
    • Summaries
      All 12
      Gene Ontology 1
      Phenotypes 4
    • Earliest
      J:193014 Cohen SP, et al., Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia. J Biol Chem. 2012 Dec 7;287(50):41706-19
    • Latest
      J:351907 Schroer AB, et al., The stability of tastant detection by mouse lingual chemosensory tissue requires Regulator of G protein Signaling-21 (RGS21). Chem Senses. 2021 Jan 1;46
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory