Flg2 MGI Mouse Gene Detail - MGI:3645678 - filaggrin family member 2

Flg2 Gene Detail

Symbol

Flg2
Name

filaggrin family member 2
Synonyms

EG229574

Feature Type

protein coding gene
IDs

MGI:3645678
NCBI Gene: 229574
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr3:93104585-93128698 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 40.14 cM
Mapping Data

1 experiment

SNPs within 2kb

358 from dbSNP Build 142
Strain Annotations

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3645678	protein coding gene	Chr3:93104585-93128701 (+)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	no annotation
C57BL/6NJ	no annotation
CAROLI/EiJ	MGP_CAROLIEiJ_G0025296	protein coding gene	Chr3:87375812-87399781 (+)
CAST/EiJ	no annotation
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	no annotation
PWK/PhJ	no annotation
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

FLG2, filaggrin 2

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FLG2, filaggrin 2
Synonyms

IFPS, PSS6
Links

HGNC:33276

NCBI Gene ID: 388698

neXtProt AC: NX_Q5D862

UniProt: Q5D862
Chr Location

1q21.3; chr1:152348735-152360006 (-) GRCh38

MGI Vertebrate Homology

Flg2 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FLG2
Gene Tree

Flg2

Diseases

1 with human FLG2 associations

				Human Disease	Mouse Models
				peeling skin syndrome 6 IDs peeling skin syndrome 6 DOID:0070525 OMIM:618084

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

4 phenotype references

All Mutations and Alleles

2
Chemically induced (other)

1
Radiation induced

1
Genomic Mutations

2 involving Flg2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

74 strains or lines available

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All GO Annotations

12
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

18
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

15
RefSeq

2
UniProt

4

Ensembl

ENSMUSG00000049133 (Evidence)
NCBI Gene

229574

			Length	Strain/Species	Flank
genomic	ENSMUSG00000049133	Ensembl Gene Model \| MGI Sequence Detail	24114	C57BL/6J	± kb
transcript	ENSMUST00000194707	Ensembl \| MGI Sequence Detail	20803	Not Applicable
polypeptide	ENSMUSP00000160002	Ensembl \| MGI Sequence Detail	6708	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000007552 filaggrin-2

(term hierarchy)
InterPro Domains

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR034325 S-100

IPR013787 S100/CaBP-9k-type, calcium binding, subdomain

IPR001751 S100/Calcium binding protein 7/8-like, conserved site

IPR052503 S100-fused Epidermal Structural Protein
GlyGen

Q2VIS4 4 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (2 sites)

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All nucleic 18

cDNA 18

Microarray probesets 1

Summaries

All 25

Developmental Gene Expression 2

Diseases 1

Gene Ontology 6

Phenotypes 4
Earliest

J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
Latest

J:320249 Godsel LM, et al., Translational implications of Th17-skewed inflammation due to genetic deficiency of a cadherin stress sensor. J Clin Invest. 2022 Feb 1;132(3):e144363

TSS for Flg2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr30320	Chr3:93104577-93104591 (+)	-1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24