About   Help   FAQ
Ighv8-6 Gene Detail
Summary
  • Symbol
    Ighv8-6
  • Name
    immunoglobulin heavy variable V8-6
  • Feature Type
    gene segment
  • IDs
    MGI:3645823
    NCBI Gene: 629930
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr12:115129397-115129697 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 62.51 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3645823
 gene segment Chr12:115129397-115129840 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0000093
 gene segment Chr12:113913506-113913944 (-)
AKR/J MGP_AKRJ_G0000098
 gene segment Chr12:117879593-117880035 (-)
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0000092
 gene segment Chr12:111760398-111949991 (-)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J MGP_LPJ_G0000099
 gene segment Chr12:118588822-118589255 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0000102
 gene segment Chr12:130322613-130323055 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0000116
 gene segment Chr12:116748654-116748954 (-)
PWK/PhJ MGP_PWKPhJ_G0000078
 gene segment Chr12:107341783-108276165 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0000087
 gene segment Chr12:117033951-117034380 (-)



Homology
more
  • Human Ortholog
    IGHV2-26, immunoglobulin heavy variable 2-26
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IGHV2-26, immunoglobulin heavy variable 2-26
  • Synonyms
    IGHV226, VH
  • Links
    NCBI Gene ID: 28455
    UniProt: A0A0B4J1V2

  • Chr Location
    14q32.33; chr14:106301395-106301862 (-)  GRCh38
  • Human Ortholog
    IGHV2-5, immunoglobulin heavy variable 2-5
  • Synonyms
    IGHV25, VH
  • Links
    NCBI Gene ID: 28457
    UniProt: P01817

  • Chr Location
    14q32.33; chr14:106037902-106038365 (-)  GRCh38
  • Human Ortholog
    IGHV2-70, immunoglobulin heavy variable 2-70
  • Synonyms
    IGHV270, VH
  • Links
    NCBI Gene ID: 28454
    UniProt: P01814

  • Chr Location
    14q32.33; chr14:106770577-106771020 (-)  GRCh38
  • Human Ortholog
    IGHV2-70D, immunoglobulin heavy variable 2-70D
  • Links
    NCBI Gene ID: 102723168
    UniProt: A0A0C4DH43

  • Chr Location
    14q32.33; chr14:106723574-106724093 (-)  GRCh38
  • Human Ortholog
    IGHV2OR16-5, immunoglobulin heavy variable 2/OR16-5 (non-functional)
  • Synonyms
    IGHV2OR165
  • Links
    NCBI Gene ID: 100129631

  • Chr Location
    16p11.2
Mutations,
Alleles, and
Phenotypes
less
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    2
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
  • All Sequences
    18
  • RefSeq
    1
  • UniProt
    2
Representative SequencesLengthStrain/SpeciesFlank
genomic 629930 NCBI Gene Model | MGI Sequence Detail 301 C57BL/6J ±  kb
polypeptide A0A0A6YXA3 UniProt | EBI | MGI Sequence Detail 118 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR050199 Immunoglobulin Heavy Variable
    IPR007110 Immunoglobulin-like domain
    IPR036179 Immunoglobulin-like domain superfamily
    IPR013783 Immunoglobulin-like fold
    IPR013106 Immunoglobulin V-set domain
References
more
  • Summaries
    All 7
    Gene Ontology 1
  • Earliest
    J:164272 Giudicelli V, et al., IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D256-61
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory