About   Help   FAQ
Tm4sf19 Gene Detail
Summary
  • Symbol
    Tm4sf19
  • Name
    transmembrane 4 L six family member 19
  • Synonyms
    EG277203
  • Feature Type
    protein coding gene
  • IDs
    MGI:3645933
    NCBI Gene: 277203
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:32219324-32227045 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 22.66 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    289 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3645933
 protein coding gene Chr16:32218823-32227397 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022737
 protein coding gene Chr16:30467718-30476975 (+)
A/J MGP_AJ_G0022702
 protein coding gene Chr16:29027243-29039306 (+)
AKR/J MGP_AKRJ_G0022675
 protein coding gene Chr16:30090014-30097690 (+)
BALB/cJ MGP_BALBcJ_G0022704
 protein coding gene Chr16:29179840-29187891 (+)
C3H/HeJ MGP_C3HHeJ_G0022469
 protein coding gene Chr16:30217553-30225060 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023153
 protein coding gene Chr16:31124214-31131990 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020671
 protein coding gene Chr16:29407891-29415894 (+)
CAST/EiJ MGP_CASTEiJ_G0021997
 protein coding gene Chr16:30340859-30350300 (+)
CBA/J MGP_CBAJ_G0022439
 protein coding gene Chr16:32369266-32379798 (+)
DBA/2J MGP_DBA2J_G0022572
 protein coding gene Chr16:28879804-28887762 (+)
FVB/NJ MGP_FVBNJ_G0022547
 protein coding gene Chr16:28865608-28873287 (+)
LP/J MGP_LPJ_G0022639
 protein coding gene Chr16:30238871-30246545 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022566
 protein coding gene Chr16:31816160-31823777 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023165
 protein coding gene Chr16:30070925-30079049 (+)
PWK/PhJ MGP_PWKPhJ_G0021736
 protein coding gene Chr16:29200477-29208183 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021567
 protein coding gene Chr16:29860654-29868286 (+)
WSB/EiJ MGP_WSBEiJ_G0022041
 protein coding gene Chr16:30019464-30027655 (+)



Homology
more
  • Human Ortholog
    TM4SF19, transmembrane 4 L six family member 19
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TM4SF19, transmembrane 4 L six family member 19
  • Synonyms
    OCTM4
  • Links
    NCBI Gene ID: 116211
    neXtProt AC: NX_Q96DZ7
    UniProt: Q96DZ7

  • Chr Location
    3q29; chr3:196319342-196338503 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    9
  • Endonuclease-mediated
    7
  • Gene trapped
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Tm4sf19
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
    17 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    2
  • cDNA Data
    2
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000079625 Ensembl Gene Model | MGI Sequence Detail 7722 C57BL/6J ±  kb
transcript ENSMUST00000115149 Ensembl | MGI Sequence Detail 1257 Not Applicable  
polypeptide ENSMUSP00000110802 Ensembl | MGI Sequence Detail 206 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR008661 L6 membrane
Molecular
Reagents
less
  • All nucleic 3
    cDNA 2
    Primer pair 1

    Microarray probesets 1
References
more
  • Summaries
    All 20
    Developmental Gene Expression 2
    Gene Ontology 1
    Phenotypes 8
  • Earliest
    J:175542 Anderson KR, et al., The L6 domain tetraspanin Tm4sf4 regulates endocrine pancreas differentiation and directed cell migration. Development. 2011 Aug;138(15):3213-24
  • Latest
    J:347000 Choi C, et al., TM4SF19-mediated control of lysosomal activity in macrophages contributes to obesity-induced inflammation and metabolic dysfunction. Nat Commun. 2024 Mar 30;15(1):2779
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory