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Clrn2 Gene Detail
Summary
  • Symbol
    Clrn2
  • Name
    clarin 2
  • Synonyms
    EG624224, mpc169H
  • Feature Type
    protein coding gene
  • IDs
    MGI:3646230
    NCBI Gene: 624224
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr5:45611093-45621491 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, Syntenic
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    455 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3646230
 protein coding gene Chr5:45611021-45621824 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029532
 protein coding gene Chr5:44156586-44166968 (+)
A/J MGP_AJ_G0029500
 protein coding gene Chr5:42622221-42632603 (+)
AKR/J MGP_AKRJ_G0029448
 protein coding gene Chr5:44111051-44122009 (+)
BALB/cJ MGP_BALBcJ_G0029509
 protein coding gene Chr5:43094898-43105264 (+)
C3H/HeJ MGP_C3HHeJ_G0029232
 protein coding gene Chr5:44116170-44127600 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029963
 protein coding gene Chr5:46246974-46257479 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027202
 protein coding gene Chr5:39792156-39802246 (+)
CAST/EiJ MGP_CASTEiJ_G0028640
 protein coding gene Chr5:43260609-43271168 (+)
CBA/J MGP_CBAJ_G0029201
 protein coding gene Chr5:47509549-47524584 (+)
DBA/2J MGP_DBA2J_G0029347
 protein coding gene Chr5:42709723-42720319 (+)
FVB/NJ MGP_FVBNJ_G0029307
 protein coding gene Chr5:42137834-42148800 (+)
LP/J MGP_LPJ_G0029432
 protein coding gene Chr5:44640991-44651375 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029335
 protein coding gene Chr5:48244263-48255483 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029996
 protein coding gene Chr5:43630274-43640653 (+)
PWK/PhJ MGP_PWKPhJ_G0028364
 protein coding gene Chr5:41835230-41845805 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028198
 protein coding gene Chr5:43070134-43081424 (+)
WSB/EiJ MGP_WSBEiJ_G0028721
 protein coding gene Chr5:43689893-43700305 (+)



Homology
more
  • Human Ortholog
    CLRN2, clarin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CLRN2, clarin 2
  • Synonyms
    DFNB117
  • Links
    NCBI Gene ID: 645104
    neXtProt AC: NX_A0PK11
    UniProt: A0PK11

  • Chr Location
    4p15.32; chr4:17515165-17527104 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CLRN2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 4 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit nonsyndromic progressive hearing loss with a lack of fast-graded voltage responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000049530 Ensembl Gene Model | MGI Sequence Detail 10399 C57BL/6J ±  kb
    transcript ENSMUST00000053250 Ensembl | MGI Sequence Detail 944 Not Applicable  
    polypeptide ENSMUSP00000058204 Ensembl | MGI Sequence Detail 232 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:5792195
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 4
      Phenotypes 26
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory