Ighv12-3 Gene Detail

Summary

• Symbol
  Ighv12-3
• Name
  immunoglobulin heavy variable V12-3

• Feature Type
  gene segment
• IDs
  MGI:3646760
  NCBI Gene: 435321
• Alliance
  gene page
• Transcription Start Sites
  1 TSS

Location &
Maps

• Sequence Map
  Chr12:114330146-114330439 bp, - strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 12, 62.36 cM
• Mapping Data
  1 experiment

Strain
Comparison

• SNPs within 2kb
  141 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3646760	gene segment	Chr12:114330141-114330574 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0000068	gene segment	Chr12:116978952-116979385 (-)
A/J	MGP_AJ_G0000072	gene segment	Chr12:112554420-112554853 (-)
AKR/J	MGP_AKRJ_G0000072	gene segment	Chr12:115825875-115826308 (-)
BALB/cJ	MGP_BALBcJ_G0000069	gene segment	Chr12:113050090-113050523 (-)
C3H/HeJ	MGP_C3HHeJ_G0000069	gene segment	Chr12:116187241-116187674 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0000092	gene segment	Chr12:120636670-120637103 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0000047	gene segment	Chr12:108909383-108909818 (-)
CAST/EiJ	MGP_CASTEiJ_G0000069	gene segment	Chr12:110965294-110965727 (-)
CBA/J	MGP_CBAJ_G0000067	gene segment	Chr12:125189673-125190106 (-)
DBA/2J	MGP_DBA2J_G0000071	gene segment	Chr12:112103562-112103995 (-)
FVB/NJ	MGP_FVBNJ_G0000065	gene segment	Chr12:110793675-110794108 (-)
LP/J	MGP_LPJ_G0000075	gene segment	Chr12:116972885-116973318 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0000073	gene segment	Chr12:128483450-128483883 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0000085	gene segment	Chr12:115228121-115228554 (-)
PWK/PhJ	MGP_PWKPhJ_G0000059	gene segment	Chr12:106734357-106734790 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0000053	gene segment	Chr12:109520887-109521320 (-)
WSB/EiJ	MGP_WSBEiJ_G0000069	gene segment	Chr12:116263767-116264200 (-)

Homology

• Human Ortholog
  IGHV4-28, immunoglobulin heavy variable 4-28

• Vertebrate Orthologs
  11

Vertebrate Orthology Source

Alliance of Genome Resources

• Human Ortholog
  IGHV4-28, immunoglobulin heavy variable 4-28
  
• Synonyms
  IGHV428, VH
• Links
  HGNC:5645

  NCBI Gene ID: 28400

  UniProt: A0A0C4DH34

  
  
• Chr Location
  14q32.33; chr14:106324254-106324760 (-)  GRCh38

---

• Human Ortholog
  IGHV4-31, immunoglobulin heavy variable 4-31
  
• Synonyms
  IGHV431
• Links
  HGNC:5649

  NCBI Gene ID: 28396

  UniProt: P0DP07

  
  
• Chr Location
  14q32.33; chr14:106349283-106349792 (-)  GRCh38

---

• Human Ortholog
  IGHV4-34, immunoglobulin heavy variable 4-34
  
• Synonyms
  IGHV434, VH
• Links
  HGNC:5650

  NCBI Gene ID: 28395

  UniProt: P06331

  
  
• Chr Location
  14q32.33; chr14:106373661-106374145 (-)  GRCh38

---

• Human Ortholog
  IGHV4-39, immunoglobulin heavy variable 4-39
  
• Synonyms
  IGHV439, VH
• Links
  HGNC:5651

  NCBI Gene ID: 28394

  UniProt: P01824

  
  
• Chr Location
  14q32.33; chr14:106421709-106422218 (-)  GRCh38

---

• Human Ortholog
  IGHV4-4, immunoglobulin heavy variable 4-4
  
• Synonyms
  IGHV44, VH
• Links
  HGNC:5652

  NCBI Gene ID: 28401

  UniProt: A0A075B6R2

  
  
• Chr Location
  14q32.33; chr14:106011922-106012420 (-)  GRCh38

---

• Human Ortholog
  IGHV4-59, immunoglobulin heavy variable 4-59
  
• Synonyms
  IGHV459, VH
• Links
  HGNC:5654

  NCBI Gene ID: 28392

  UniProt: P01825

  
  
• Chr Location
  14q32.33; chr14:106627249-106627825 (-)  GRCh38

---

• Human Ortholog
  IGHV4-61, immunoglobulin heavy variable 4-61
  
• Synonyms
  IGHV461, VH
• Links
  HGNC:5655

  NCBI Gene ID: 28391

  UniProt: A0A0C4DH41

  
  
• Chr Location
  14q32.33; chr14:106639119-106639657 (-)  GRCh38

---

• Human Ortholog
  IGHV4OR15-8, immunoglobulin heavy variable 4/OR15-8 (non-functional)
  
• Synonyms
  IGHV4OR158, VSIG6
• Links
  HGNC:5658

  NCBI Gene ID: 28317

  
  
• Chr Location
  15q11.2; chr15:22184967-22185402 (-)  GRCh38

---

• Human Ortholog
  IGHV6-1, immunoglobulin heavy variable 6-1
  
• Synonyms
  IGHV61, VH
• Links
  HGNC:5662

  NCBI Gene ID: 28385

  UniProt: A0A0B4J1U7

  
  
• Chr Location
  14q32.33; chr14:105939754-105940253 (-)  GRCh38

---

• MGI Vertebrate Homology
  Ighv12-3 stringent orthology
  9 human;1 mouse;2 zebrafish
  
• HCOP
  vertebrate homology predictions: IGHV4-28, IGHV4-31, IGHV4-34, IGHV4-39, IGHV4-4, IGHV4-59, IGHV4-61, IGHV4OR15-8, IGHV6-1
• Gene Tree
  Ighv12-3
  

Mutations,
Alleles, and
Phenotypes

• Incidental Mutations
  APF
• Find Mice (IMSR)
  6 strains or lines available

Gene Ontology
(GO)
Classifications

• All GO Annotations
  2
• GO References
  1

Expression

• Assay Results
  706

Tissue x Stage Matrix

• Other Mouse Links
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  24
• RefSeq
  1
• UniProt
  1

• Ensembl
  ENSMUSG00000076676 (Evidence)
• NCBI Gene
  435321

Representative Sequences			Length	Strain/Species
genomic	435321	NCBI Gene Model | MGI Sequence Detail	294	C57BL/6J
polypeptide	A0A075B5T1	UniProt | EBI | MGI Sequence Detail	117	Not Applicable

Protein
Information

• UniProt
  1 Sequence
• InterPro Domains
  IPR050199 Immunoglobulin Heavy Variable
  IPR007110 Immunoglobulin-like domain
  IPR036179 Immunoglobulin-like domain superfamily
  IPR013783 Immunoglobulin-like fold
  IPR013106 Immunoglobulin V-set domain

References

• Summaries
  All 7

  Gene Ontology 1
• Earliest
  J:164272 Giudicelli V, et al., IMGT/GENE-DB: a comprehensive database for human and mouse immunoglobulin and T cell receptor genes. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D256-61

TSS for Ighv12-3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr118074	Chr12:114330627-114330632 (-)	-191 bp