Fscb MGI Mouse Gene Detail - MGI:3646964 - fibrous sheath CABYR binding protein

Symbol

Fscb
Name

fibrous sheath CABYR binding protein
Synonyms

EG623046

Feature Type

protein coding gene
IDs

MGI:3646964
NCBI Gene: 623046
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr12:64518104-64521464 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 26.96 cM
Mapping Data

1 experiment

SNPs within 2kb

146 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3646964	protein coding gene	Chr12:64518104-64521672 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019774	protein coding gene	Chr12:63935184-63938785 (-)
A/J	MGP_AJ_G0019733	protein coding gene	Chr12:61566076-61569677 (-)
AKR/J	MGP_AKRJ_G0019708	protein coding gene	Chr12:63530024-63533445 (-)
BALB/cJ	MGP_BALBcJ_G0019713	protein coding gene	Chr12:62017718-62021319 (-)
C3H/HeJ	MGP_C3HHeJ_G0019518	protein coding gene	Chr12:63855941-63859542 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020165	protein coding gene	Chr12:65933119-65936756 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017785	protein coding gene	Chr12:59403900-59407533 (-)
CAST/EiJ	MGP_CASTEiJ_G0019070	protein coding gene	Chr12:58587565-58591166 (-)
CBA/J	MGP_CBAJ_G0019487	protein coding gene	Chr12:68331607-68335208 (-)
DBA/2J	MGP_DBA2J_G0019603	protein coding gene	Chr12:61494252-61497817 (-)
FVB/NJ	MGP_FVBNJ_G0019591	protein coding gene	Chr12:60558353-60561954 (-)
LP/J	MGP_LPJ_G0019675	protein coding gene	Chr12:63937161-63940762 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019629	protein coding gene	Chr12:71153868-71157469 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020199	protein coding gene	Chr12:62920336-62923937 (-)
PWK/PhJ	MGP_PWKPhJ_G0018836	protein coding gene	Chr12:55748075-55781943 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018630	protein coding gene	Chr12:57213599-57248857 (-)
WSB/EiJ	MGP_WSBEiJ_G0019121	protein coding gene	Chr12:63427324-63430889 (-)

Human Ortholog

FSCB, fibrous sheath CABYR binding protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FSCB, fibrous sheath CABYR binding protein
Synonyms

C14orf155
Links

HGNC:20494

NCBI Gene ID: 84075

neXtProt AC: NX_Q5H9T9

UniProt: Q5H9T9
Chr Location

14q21.2; chr14:44504149-44507283 (-) GRCh38

MGI Vertebrate Homology

Fscb stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: FSCB
Gene Tree

Fscb

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Phenotype Summary

6 phenotypes from 3 alleles in 2 genetic backgrounds
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Endonuclease-mediated

5
Genomic Mutations

1 involving Fscb
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

47 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice exhibit normal male fertility.

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All GO Annotations

10
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

748
Tissues

19
cDNA Data

2
Literature Summary

1

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas

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All Sequences

27
RefSeq

2
UniProt

2
CCDS

CCDS49073.1

Ensembl

ENSMUSG00000043060 (Evidence)
NCBI Gene

623046

			Length	Strain/Species	Flank
genomic	ENSMUSG00000043060	Ensembl Gene Model \| MGI Sequence Detail	3361	C57BL/6J	± kb
transcript	ENSMUST00000059833	Ensembl \| MGI Sequence Detail	3361	Not Applicable
polypeptide	ENSMUSP00000051554	Ensembl \| MGI Sequence Detail	1062	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007676 fibrous sheath CABYR-binding protein

(term hierarchy)
InterPro Domains

IPR043375 Fibrous sheath CABYR-binding protein

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All nucleic 2

cDNA 2

Microarray probesets 1

Summaries

All 19

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 7
Earliest

J:128382 Li YF, et al., FSCB, a novel protein kinase A-phosphorylated calcium-binding protein, is a CABYR-binding partner involved in late steps of fibrous sheath biogenesis. J Biol Chem. 2007 Nov 23;282(47):34104-19
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Fscb:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr3851	Chr12:64521691-64521694 (-)	-229 bp
Tssr116460	Chr12:64521659-64521685 (-)	-208 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24