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Defb33 Gene Detail
Summary
  • Symbol
    Defb33
  • Name
    defensin beta 33
  • Synonyms
    EG654453
  • Feature Type
    protein coding gene
  • IDs
    MGI:3647176
    NCBI Gene: 654453
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:21382685-21387739 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, Syntenic
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    274 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3647176
 protein coding gene Chr8:21382683-21387739 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033422
 protein coding gene Chr8:18656151-18661199 (+)
A/J MGP_AJ_G0033403
 protein coding gene Chr8:18041079-18046129 (+)
AKR/J MGP_AKRJ_G0033332
 protein coding gene Chr8:18689203-18694263 (+)
BALB/cJ MGP_BALBcJ_G0033404
 protein coding gene Chr8:18175811-18180861 (+)
C3H/HeJ MGP_C3HHeJ_G0033114
 protein coding gene Chr8:18869453-18874503 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033917
 protein coding gene Chr8:19269342-19274396 (+)
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0032438
 protein coding gene Chr8:18323336-18328342 (+)
CBA/J MGP_CBAJ_G0033088
 protein coding gene Chr8:20240053-20245103 (+)
DBA/2J MGP_DBA2J_G0033244
 protein coding gene Chr8:18043363-18048413 (+)
FVB/NJ MGP_FVBNJ_G0033189
 protein coding gene Chr8:17767943-17772993 (+)
LP/J MGP_LPJ_G0033336
 protein coding gene Chr8:18716107-18721150 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033228
 protein coding gene Chr8:19952754-19957792 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033935
 protein coding gene Chr8:18571059-18576113 (+)
PWK/PhJ MGP_PWKPhJ_G0032150
 protein coding gene Chr8:17787200-17792299 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031990
 protein coding gene Chr8:18079164-18084173 (+)
WSB/EiJ MGP_WSBEiJ_G0032555
 protein coding gene Chr8:18737668-18742734 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000074454 Ensembl Gene Model | MGI Sequence Detail 5055 C57BL/6J ±  kb
transcript ENSMUST00000098908 Ensembl | MGI Sequence Detail 424 Not Applicable  
polypeptide ENSMUSP00000096507 Ensembl | MGI Sequence Detail 62 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 1
References
more
  • Summaries
    All 15
    Gene Ontology 3
    Phenotypes 2
  • Earliest
    J:156769 Amid C, et al., Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome. BMC Genomics. 2009;10:606
  • Latest
    J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory