Meiosin MGI Mouse Gene Detail - MGI:3647482

Symbol

Meiosin
Name

meiosis initiator
Synonyms

Bhmg1

Feature Type

protein coding gene
IDs

MGI:3647482
NCBI Gene: 243866
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr7:18832971-18852293 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 9.46 cM
Mapping Data

1 experiment

SNPs within 2kb

393 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3647482	protein coding gene	Chr7:18832196-18852456 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0031759	protein coding gene	Chr7:17052099-17072813 (-)
A/J	MGP_AJ_G0031735	protein coding gene	Chr7:16739257-16759324 (-)
AKR/J	MGP_AKRJ_G0031661	protein coding gene	Chr7:17198173-17217247 (-)
BALB/cJ	MGP_BALBcJ_G0031740	protein coding gene	Chr7:16932637-16951724 (-)
C3H/HeJ	MGP_C3HHeJ_G0031462	protein coding gene	Chr7:17458348-17478322 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032206	protein coding gene	Chr7:17942321-17963679 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029272	protein coding gene	Chr7:18387787-18405900 (-)
CAST/EiJ	MGP_CASTEiJ_G0030805	protein coding gene	Chr7:13859828-13878927 (-)
CBA/J	MGP_CBAJ_G0031424	protein coding gene	Chr7:18594211-18613472 (-)
DBA/2J	MGP_DBA2J_G0031579	protein coding gene	Chr7:16674912-16695401 (-)
FVB/NJ	MGP_FVBNJ_G0031531	protein coding gene	Chr7:16539185-16559361 (-)
LP/J	MGP_LPJ_G0031662	protein coding gene	Chr7:17396803-17417531 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0031567	protein coding gene	Chr7:18454317-18474900 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032234	protein coding gene	Chr7:16805073-16826161 (-)
PWK/PhJ	MGP_PWKPhJ_G0030529	protein coding gene	Chr7:13763832-13783404 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030356	protein coding gene	Chr7:11489071-11510546 (-)
WSB/EiJ	MGP_WSBEiJ_G0030905	protein coding gene	Chr7:17010294-17031457 (-)

Human Ortholog

MEIOSIN, meiosis initiator

Vertebrate Orthologs

1

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MEIOSIN, meiosis initiator
Synonyms

BHMG1, HMGDC
Links

HGNC:44318

NCBI Gene ID: 388553

neXtProt AC: NX_C9JSJ3

UniProt: C9JSJ3
Chr Location

19q13.32; chr19:45733439-45764541 (+) GRCh38

MGI Vertebrate Homology

Meiosin stringent orthology
1 human;1 mouse
HCOP

vertebrate homology predictions: MEIOSIN
Gene Tree

Meiosin

less

Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
3 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

2
Endonuclease-mediated

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout affects meiosis during spermatogenesis and oocytogenesis and results in male and female sterility.

less

All GO Annotations

10
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

794
Tissues

73
cDNA Data

5
Literature Summary

4

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

less

All Sequences

56
RefSeq

28
UniProt

2

Ensembl

ENSMUSG00000085601 (Evidence)
NCBI Gene

243866

			Length	Strain/Species	Flank
genomic	ENSMUSG00000085601	Ensembl Gene Model \| MGI Sequence Detail	19323	C57BL/6J	± kb
transcript	ENSMUST00000141380	Ensembl \| MGI Sequence Detail	1892	Not Applicable
polypeptide	ENSMUSP00000115575	Ensembl \| MGI Sequence Detail	566	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000059731 meiosis initiator protein

(term hierarchy)
InterPro Domains

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR009071 High mobility group box domain

IPR036910 High mobility group box domain superfamily

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

less

All nucleic 6

cDNA 5

Primer pair 1

less

MGI:6389028, MGI:6441032

Summaries

All 17

Developmental Gene Expression 4

Gene Ontology 3

Phenotypes 3
Earliest

J:91257 Gray PA, et al., Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
Latest

J:342011 Shimada R, et al., STRA8-RB interaction is required for timely entry of meiosis in mouse female germ cells. Nat Commun. 2023 Oct 25;14(1):6443

TSS for Meiosin:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr70870	Chr7:18852282-18852329 (-)	-13 bp
Tssr70869	Chr7:18852257-18852278 (-)	25 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24