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Defa43 Gene Detail
Summary
  • Symbol
    Defa43
  • Name
    defensin, alpha, 43
  • Synonyms
    Gm7861
  • Feature Type
    protein coding gene
  • IDs
    MGI:3648003
    NCBI Gene: 665956
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr8:22083503-22084481 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 10.35 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3648003
 protein coding gene Chr8:22083391-22084524 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033426
 protein coding gene Chr8:18854307-18855451 (-)
A/J MGP_AJ_G0033406
 protein coding gene Chr8:18884602-18887256 (-)
AKR/J MGP_AKRJ_G0033336
 protein coding gene Chr8:19252518-19253564 (-)
BALB/cJ no annotation
C3H/HeJ MGP_C3HHeJ_G0033117
 protein coding gene Chr8:19657303-19658978 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0030881
 protein coding gene Chr8:15504475-15505539 (-)
CAST/EiJ MGP_CASTEiJ_G0032444
 protein coding gene Chr8:19119733-19120867 (-)
CBA/J MGP_CBAJ_G0033094
 protein coding gene Chr8:21135145-21137859 (-)
DBA/2J MGP_DBA2J_G0033247
 protein coding gene Chr8:18861079-18862464 (-)
FVB/NJ MGP_FVBNJ_G0033192
 protein coding gene Chr8:18512439-18515823 (-)
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0033234
 protein coding gene Chr8:20782211-20783341 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0033939
 protein coding gene Chr8:18776286-18776670 (-)
PWK/PhJ MGP_PWKPhJ_G0032156
 protein coding gene Chr8:18272678-18273802 (-)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0032563
 protein coding gene Chr8:19525171-19526300 (-)



Homology
more
  • Human Ortholog
    DEFA4, defensin alpha 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFA4, defensin alpha 4
  • Synonyms
    DEF4, HNP-4, HP-4, HP4
  • Links
    NCBI Gene ID: 1669
    neXtProt AC: NX_P12838
    UniProt: P12838

  • Chr Location
    8p23.1; chr8:6935820-6938306 (-)  GRCh38
  • Human Ortholog
    DEFA6, defensin alpha 6
  • Synonyms
    DEF6, HD-6
  • Links
    NCBI Gene ID: 1671
    neXtProt AC: NX_Q01524
    UniProt: Q01524

  • Chr Location
    8p23.1; chr8:6924697-6926076 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    1
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 665956 NCBI Gene Model | MGI Sequence Detail 979 C57BL/6J ±  kb
transcript NM_001177526 RefSeq | MGI Sequence Detail 351 C57BL/6  
polypeptide NP_001170997 RefSeq | MGI Sequence Detail 116 C57BL/6  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
  • InterPro Domains
    IPR016327 Alpha-defensin
    IPR002366 Alpha-defensin, N-terminal
Other
Accession IDs
less
MGI:6336193
References
more
  • Summaries
    All 11
    Gene Ontology 1
    Phenotypes 4
  • Earliest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
  • Latest
    J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory