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Defb18 Gene Detail
Summary
  • Symbol
    Defb18
  • Name
    defensin beta 18
  • Synonyms
    EG654460
  • Feature Type
    protein coding gene
  • IDs
    MGI:3648148
    NCBI Gene: 654460
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:18306697-18307667 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 5.70 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    135 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3648148
 protein coding gene Chr1:18306626-18307700 (-)
129S1/SvImJ MGP_129S1SvImJ_G0015865
 protein coding gene Chr1:15824763-15825733 (-)
A/J MGP_AJ_G0015846
 protein coding gene Chr1:15611764-15612734 (-)
AKR/J MGP_AKRJ_G0015805
 protein coding gene Chr1:15595018-15595988 (-)
BALB/cJ MGP_BALBcJ_G0015802
 protein coding gene Chr1:15297999-15298969 (-)
C3H/HeJ MGP_C3HHeJ_G0015636
 protein coding gene Chr1:15679366-15680336 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016256
 protein coding gene Chr1:16514067-16515037 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0013977
 protein coding gene Chr1:14029748-14030715 (-)
CAST/EiJ MGP_CASTEiJ_G0015217
 protein coding gene Chr1:15752342-15753313 (-)
CBA/J MGP_CBAJ_G0015609
 protein coding gene Chr1:16867291-16868261 (-)
DBA/2J MGP_DBA2J_G0015708
 protein coding gene Chr1:15188733-15189703 (-)
FVB/NJ MGP_FVBNJ_G0015713
 protein coding gene Chr1:14967150-14968120 (-)
LP/J MGP_LPJ_G0015780
 protein coding gene Chr1:16020526-16021496 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015732
 protein coding gene Chr1:17719127-17720230 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016303
 protein coding gene Chr1:15566928-15567898 (-)
PWK/PhJ MGP_PWKPhJ_G0015001
 protein coding gene Chr1:14938641-14939611 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014782
 protein coding gene Chr1:15698801-15699788 (-)
WSB/EiJ MGP_WSBEiJ_G0015280
 protein coding gene Chr1:15557452-15558422 (-)



Homology
more
  • Human Ortholog
    DEFB113, defensin beta 113
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFB113, defensin beta 113
  • Synonyms
    DEFB-13
  • Links
    NCBI Gene ID: 245927
    neXtProt AC: NX_Q30KQ7
    UniProt: Q30KQ7

  • Chr Location
    6p12.3; chr6:49968677-49969625 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    3
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000073735 Ensembl Gene Model | MGI Sequence Detail 971 C57BL/6J ±  kb
transcript ENSMUST00000097818 Ensembl | MGI Sequence Detail 258 Not Applicable  
polypeptide ENSMUSP00000095427 Ensembl | MGI Sequence Detail 85 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 1
References
more
  • Summaries
    All 16
    Gene Ontology 3
    Phenotypes 4
  • Earliest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory