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Klhdc7b Gene Detail
Summary
  • Symbol
    Klhdc7b
  • Name
    kelch domain containing 7B
  • Synonyms
    EG546648
  • Feature Type
    protein coding gene
  • IDs
    MGI:3648212
    NCBI Gene: 546648
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:89269120-89273070 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 44.87 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    210 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3648212
 protein coding gene Chr15:89268262-89274025 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022232
 protein coding gene Chr15:90579343-90581383 (+)
A/J MGP_AJ_G0022191
 protein coding gene Chr15:87114817-87116857 (+)
AKR/J MGP_AKRJ_G0022166
 protein coding gene Chr15:89692909-89694949 (+)
BALB/cJ MGP_BALBcJ_G0022197
 protein coding gene Chr15:87219654-87221694 (+)
C3H/HeJ MGP_C3HHeJ_G0021967
 protein coding gene Chr15:89689558-89691598 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022642
 protein coding gene Chr15:93869682-93871722 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020167
 protein coding gene Chr15:83341912-83343952 (+)
CAST/EiJ MGP_CASTEiJ_G0021489
 protein coding gene Chr15:90466157-90468197 (+)
CBA/J MGP_CBAJ_G0021934
 protein coding gene Chr15:97055613-97057653 (+)
DBA/2J MGP_DBA2J_G0022061
 protein coding gene Chr15:86565088-86567128 (+)
FVB/NJ MGP_FVBNJ_G0022040
 protein coding gene Chr15:85630676-85632716 (+)
LP/J MGP_LPJ_G0022132
 protein coding gene Chr15:90736118-90738158 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022060
 protein coding gene Chr15:101453439-101455479 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022657
 protein coding gene Chr15:89728615-89730655 (+)
PWK/PhJ MGP_PWKPhJ_G0021230
 protein coding gene Chr15:86627954-86629994 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021064
 protein coding gene Chr15:89477397-89479437 (+)
WSB/EiJ MGP_WSBEiJ_G0021538
 protein coding gene Chr15:90217295-90219335 (+)



Homology
more
  • Human Ortholog
    KLHDC7B, kelch domain containing 7B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLHDC7B, kelch domain containing 7B
  • Links
    NCBI Gene ID: 113730
    neXtProt AC: NX_Q96G42
    UniProt: Q96G42

  • Chr Location
    22q13.33; chr22:50545899-50551023 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000091680 Ensembl Gene Model | MGI Sequence Detail 3951 C57BL/6J ±  kb
    transcript ENSMUST00000225666 Ensembl | MGI Sequence Detail 3951 Not Applicable  
    polypeptide ENSMUSP00000153286 Ensembl | MGI Sequence Detail 1263 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR052310 Kelch/BTB domain-containing protein
      IPR006652 Kelch repeat type 1
      IPR015915 Kelch-type beta propeller
    References
    more
    • Summaries
      All 30
      Diseases 1
      Phenotypes 23
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory