Tstd1 MGI Mouse Gene Detail - MGI:3648482 - thiosulfate sulfurtransferase (rhodanese)-like domain containing 1

Symbol

Tstd1
Name

thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
Synonyms

Gm4848

Feature Type

protein coding gene
IDs

MGI:3648482
NCBI Gene: 226654
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr1:171246601-171247920 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 79.41 cM
Mapping Data

2 experiments

SNPs within 2kb

155 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3648482	protein coding gene	Chr1:171246440-171247920 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016762	protein coding gene	Chr1:177220335-177221815 (+)
A/J	MGP_AJ_G0016742	protein coding gene	Chr1:169995565-169997045 (+)
AKR/J	MGP_AKRJ_G0016708	protein coding gene	Chr1:175091432-175092912 (+)
BALB/cJ	MGP_BALBcJ_G0016703	protein coding gene	Chr1:170490401-170491881 (+)
C3H/HeJ	MGP_C3HHeJ_G0016526	protein coding gene	Chr1:175344739-175346219 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017164	protein coding gene	Chr1:183111517-183112997 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014872	protein coding gene	Chr1:161684453-161685959 (+)
CAST/EiJ	MGP_CASTEiJ_G0016107	protein coding gene	Chr1:174969129-174970634 (+)
CBA/J	MGP_CBAJ_G0016501	protein coding gene	Chr1:189621819-189623299 (+)
DBA/2J	MGP_DBA2J_G0016608	protein coding gene	Chr1:168838253-168839733 (+)
FVB/NJ	MGP_FVBNJ_G0016604	protein coding gene	Chr1:167190225-167191705 (+)
LP/J	MGP_LPJ_G0016679	protein coding gene	Chr1:178330890-178332370 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016631	protein coding gene	Chr1:196897960-196899448 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017201	protein coding gene	Chr1:174959944-174961424 (+)
PWK/PhJ	MGP_PWKPhJ_G0015893	protein coding gene	Chr1:168061974-168063454 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015677	protein coding gene	Chr1:173752136-173753656 (+)
WSB/EiJ	MGP_WSBEiJ_G0016169	protein coding gene	Chr1:175081095-175082575 (+)

Human Ortholog

TSTD1, thiosulfate sulfurtransferase like domain containing 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TSTD1, thiosulfate sulfurtransferase like domain containing 1
Synonyms

KAT, TST
Links

HGNC:35410

NCBI Gene ID: 100131187

neXtProt AC: NX_Q8NFU3

UniProt: Q8NFU3
Chr Location

1q23.3; chr1:161037631-161038977 (-) GRCh38

MGI Vertebrate Homology

Tstd1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TSTD1
Gene Tree

Tstd1

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

2
Targeted

1
Genomic Mutations

2 involving Tstd1
Find Mice (IMSR)

4 strains or lines available

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All GO Annotations

5
GO References

3

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

5

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tstd1

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All Sequences

31
RefSeq

2
UniProt

1
CCDS

CCDS48443.1

Ensembl

ENSMUSG00000103711 (Evidence)
NCBI Gene

226654

			Length	Strain/Species	Flank
genomic	226654	NCBI Gene Model \| MGI Sequence Detail	1320	C57BL/6J	± kb
transcript	NM_001164525	RefSeq \| MGI Sequence Detail	551	C57BL/6
polypeptide	NP_001157997	RefSeq \| MGI Sequence Detail	133	C57BL/6

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UniProt

1 Sequence
InterPro Domains

IPR001763 Rhodanese-like domain

IPR036873 Rhodanese-like domain superfamily

IPR042457 Thiosulfate:glutathione sulfurtransferase, mammalian

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All nucleic 5

cDNA 5

Microarray probesets 1

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MGI:2138518

Summaries

All 25

Gene Ontology 3

Phenotypes 8
Earliest

J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tstd1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10051	Chr1:171246532-171246537 (+)	-66 bp
Tssr10052	Chr1:171246595-171246620 (+)	7 bp
Tssr10053	Chr1:171246628-171246660 (+)	43 bp
Tssr289	Chr1:171246662-171246667 (+)	64 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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