About   Help   FAQ
Pierce2 Gene Detail
Summary
  • Symbol
    Pierce2
  • Name
    piercer of microtubule wall 2
  • Synonyms
    Ccpg1os, Gm5918
  • Feature Type
    protein coding gene
  • IDs
    MGI:3648770
    NCBI Gene: 546143
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:72886999-72892658 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 40.08 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    196 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3648770
 protein coding gene Chr9:72886964-72892674 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035022
 protein coding gene Chr9:73181145-73189019 (-)
A/J MGP_AJ_G0035003
 protein coding gene Chr9:70623953-70629606 (-)
AKR/J MGP_AKRJ_G0034932
 protein coding gene Chr9:72316046-72323030 (-)
BALB/cJ MGP_BALBcJ_G0034995
 protein coding gene Chr9:70331434-70337427 (-)
C3H/HeJ MGP_C3HHeJ_G0034704
 protein coding gene Chr9:72808012-72813549 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035514
 protein coding gene Chr9:75106143-75112291 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032425
 protein coding gene Chr9:70098270-70101514 (-)
CAST/EiJ MGP_CASTEiJ_G0034026
 protein coding gene Chr9:73145908-73154000 (-)
CBA/J MGP_CBAJ_G0034677
 protein coding gene Chr9:77723414-77728859 (-)
DBA/2J MGP_DBA2J_G0034836
 protein coding gene Chr9:70341058-70346825 (-)
FVB/NJ MGP_FVBNJ_G0034778
 protein coding gene Chr9:69650820-69656243 (-)
LP/J MGP_LPJ_G0034917
 protein coding gene Chr9:73405824-73411213 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034819
 protein coding gene Chr9:78801821-78809912 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035536
 protein coding gene Chr9:72468143-72476143 (-)
PWK/PhJ MGP_PWKPhJ_G0033730
 protein coding gene Chr9:70617851-70623361 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033563
 protein coding gene Chr9:72757892-72763302 (-)
WSB/EiJ MGP_WSBEiJ_G0034138
 protein coding gene Chr9:72406875-72412376 (-)



Homology
more
  • Human Ortholog
    PIERCE2, piercer of microtubule wall 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIERCE2, piercer of microtubule wall 2
  • Synonyms
    C14orf65, C15orf65
  • Links
    NCBI Gene ID: 145788
    neXtProt AC: NX_H3BRN8
    UniProt: H3BRN8

  • Chr Location
    15q21.3; chr15:55408495-55418798 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit reduced nodal cilia beating frequency without disruption of left right axis patterning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    6
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    5
  • cDNA Data
    22
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 546143 NCBI Gene Model | MGI Sequence Detail 5660 C57BL/6J ±  kb
    transcript NM_001198789 RefSeq | MGI Sequence Detail 722 C57BL/6  
    polypeptide V9GXK1 UniProt | EBI | MGI Sequence Detail 122 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 22

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:6852591
    References
    more
    • Summaries
      All 26
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 8
    • Earliest
      J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory