Mcidas MGI Mouse Gene Detail - MGI:3648807 - multiciliate differentiation and DNA synthesis associated cell cycle protein

Symbol

Mcidas
Name

multiciliate differentiation and DNA synthesis associated cell cycle protein
Synonyms

Gm6320, Idas, Mci, Mcin, multicilin

Feature Type

protein coding gene
IDs

MGI:3648807
NCBI Gene: 622408
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr13:113130379-113136928 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 63.93 cM
Mapping Data

1 experiment

SNPs within 2kb

286 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_3648807	protein coding gene	Chr13:113130104-113138233 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020944	protein coding gene	Chr13:115596435-115602966 (+)
A/J	MGP_AJ_G0020894	protein coding gene	Chr13:110975331-110981716 (+)
AKR/J	MGP_AKRJ_G0020869	protein coding gene	Chr13:114322147-114328676 (+)
BALB/cJ	MGP_BALBcJ_G0020894	protein coding gene	Chr13:111668459-111674988 (+)
C3H/HeJ	MGP_C3HHeJ_G0020683	protein coding gene	Chr13:114117545-114124080 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0021330	protein coding gene	Chr13:119013855-119020381 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018899	protein coding gene	Chr13:106266657-106272897 (+)
CAST/EiJ	MGP_CASTEiJ_G0020203	protein coding gene	Chr13:113753660-113760066 (+)
CBA/J	MGP_CBAJ_G0020645	protein coding gene	Chr13:123617678-123624209 (+)
DBA/2J	MGP_DBA2J_G0020768	protein coding gene	Chr13:110685368-110693272 (+)
FVB/NJ	MGP_FVBNJ_G0020752	protein coding gene	Chr13:109386832-109393551 (+)
LP/J	MGP_LPJ_G0020844	protein coding gene	Chr13:115629041-115636692 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020780	protein coding gene	Chr13:123875899-123882420 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0021366	protein coding gene	Chr13:113787866-113794266 (+)
PWK/PhJ	MGP_PWKPhJ_G0019956	protein coding gene	Chr13:109434980-109441377 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019778	protein coding gene	Chr13:110106548-110112925 (+)
WSB/EiJ	MGP_WSBEiJ_G0020260	protein coding gene	Chr13:114384882-114391244 (+)

Human Ortholog

MCIDAS, multiciliate differentiation and DNA synthesis associated cell cycle protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MCIDAS, multiciliate differentiation and DNA synthesis associated cell cycle protein
Synonyms

CILD42, IDAS, MCI, MCIN
Links

HGNC:40050

NCBI Gene ID: 345643

neXtProt AC: NX_D6RGH6

UniProt: D6RGH6
Chr Location

5q11.2; chr5:55219564-55227315 (-) GRCh38

MGI Vertebrate Homology

Mcidas stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MCIDAS
Gene Tree

Mcidas

Diseases

1 with human MCIDAS associations

				Human Disease	Mouse Models
				primary ciliary dyskinesia 42 IDs primary ciliary dyskinesia 42 DOID:0111855 OMIM:618695

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

26 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

3
Incidental Mutations

APF
Find Mice (IMSR)

17 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a null allele show postnatal death, hydrocephaly, small size, sterility, and loss of multiple ciliated cells (MCCs) in the trachea, oviducts and brain ependyma. Although MCC precursors are specified, they fail to produce multiple basal bodies and mature into single ciliated cells.

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All GO Annotations

29
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

757
Tissues

28
cDNA Data

5
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mcidas

ZFIN mcidas

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All Sequences

29
RefSeq

4
UniProt

1
CCDS

CCDS36783.1

Ensembl

ENSMUSG00000074651 (Evidence)
NCBI Gene

622408

			Length	Strain/Species	Flank
genomic	ENSMUSG00000074651	Ensembl Gene Model \| MGI Sequence Detail	6550	C57BL/6J	± kb
transcript	ENSMUST00000092089	Ensembl \| MGI Sequence Detail	2377	Not Applicable
polypeptide	ENSMUSP00000089721	Ensembl \| MGI Sequence Detail	379	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000032672 multicilin

(term hierarchy)
InterPro Domains

IPR022786 Geminin/Multicilin

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All nucleic 6

cDNA 5

Primer pair 1

Microarray probesets 1

Summaries

All 30

Developmental Gene Expression 9

Gene Ontology 6

Phenotypes 6
Earliest

J:344854 Pefani DE, et al., Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression. J Biol Chem. 2011 Jul;286(26):23234-46
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mcidas:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr121159	Chr13:113130327-113130354 (+)	-38 bp
Tssr121160	Chr13:113130356-113130372 (+)	-15 bp
Tssr121161	Chr13:113130374-113130403 (+)	10 bp
Tssr121162	Chr13:113130418-113130429 (+)	45 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24