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Dnmt3c Gene Detail
Summary
  • Symbol
    Dnmt3c
  • Name
    DNA methyltransferase 3C
  • Synonyms
    Dnmt3c-ps, Gm14490
  • Feature Type
    protein coding gene
  • IDs
    MGI:3649996
    NCBI Gene: 668932
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr2:153538572-153571827 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, Syntenic
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1079 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3649996
 protein coding gene Chr2:153538572-153572352 (+)
129S1/SvImJ MGP_129S1SvImJ_G0040280
 pseudogene Chr2:158372771-158417887 (+)
A/J MGP_AJ_G0040262
 pseudogene Chr2:152016279-152052320 (+)
AKR/J MGP_AKRJ_G0040196
 pseudogene Chr2:156468630-156512885 (+)
BALB/cJ MGP_BALBcJ_G0040261
 pseudogene Chr2:152325797-152377944 (+)
C3H/HeJ MGP_C3HHeJ_G0039896
 pseudogene Chr2:156858159-156894693 (+)
C57BL/6NJ MGP_C57BL6NJ_G0040853
 pseudogene Chr2:162979384-163034677 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0037284
 pseudogene Chr2:145588138-145622576 (+)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0039864
 pseudogene Chr2:168995764-169039405 (+)
DBA/2J MGP_DBA2J_G0040062
 pseudogene Chr2:151241431-151276888 (+)
FVB/NJ MGP_FVBNJ_G0040019
 pseudogene Chr2:149694656-149727359 (+)
LP/J MGP_LPJ_G0040110
 pseudogene Chr2:158505277-158547401 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0040015
 pseudogene Chr2:172974903-173019274 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0040952
 pseudogene Chr2:156376650-156413173 (+)
PWK/PhJ MGP_PWKPhJ_G0038676
 pseudogene Chr2:150764095-150804941 (+)
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0039203
 pseudogene Chr2:157269434-157313329 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 6 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU or endonuclease-mediated mutation alleles exhibit reduced transposon and retrotransposons in male germ cells, male infertility, meiotic arrest, azoospermia and hypogonadism.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    23
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      24
    • RefSeq
      2
    • UniProt
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000082079 Ensembl Gene Model | MGI Sequence Detail 33256 C57BL/6J ±  kb
    transcript ENSMUST00000119996 Ensembl | MGI Sequence Detail 2223 Not Applicable  
    polypeptide ENSMUSP00000153622 Ensembl | MGI Sequence Detail 740 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • PDB
      8TCI
    • EC
      2.1.1.37
    • InterPro Domains
      IPR025766 ADD domain
      IPR001525 C-5 cytosine methyltransferase
      IPR018117 DNA methylase, C-5 cytosine-specific, active site
      IPR049554 DNMT3, ADD domain, PHD zinc finger
      IPR040552 DNMT3, cysteine rich ADD domain, GATA1-like zinc finger
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase superfamily
      IPR011011 Zinc finger, FYVE/PHD-type
    Other
    Accession IDs
    less
    MGI:2674155, MGI:5882783
    References
    more
    • Summaries
      All 20
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:91812 Stryke D, et al., BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Nucleic Acids Res. 2003 Jan 1;31(1):278-81
    • Latest
      J:355645 Khudaverdyan N, et al., The structure of DNA methyltransferase DNMT3C reveals an activity-tuning mechanism for DNA methylation. J Biol Chem. 2024 Aug 2;300(9):107633
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory