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Ctcfl Gene Detail
Summary
  • Symbol
    Ctcfl
  • Name
    CCCTC-binding factor like
  • Synonyms
    Boris, OTTMUSG00000016680
  • Feature Type
    protein coding gene
  • IDs
    MGI:3652571
    NCBI Gene: 664799
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:172935402-172961318 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 95.74 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    935 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3652571
 protein coding gene Chr2:172935402-172961318 (-)
129S1/SvImJ MGP_129S1SvImJ_G0026953
 protein coding gene Chr2:179340716-179368059 (-)
A/J MGP_AJ_G0026920
 protein coding gene Chr2:171801340-171828448 (-)
AKR/J MGP_AKRJ_G0026891
 protein coding gene Chr2:176984070-177015416 (-)
BALB/cJ MGP_BALBcJ_G0026929
 protein coding gene Chr2:172202276-172228071 (-)
C3H/HeJ MGP_C3HHeJ_G0026671
 protein coding gene Chr2:177373503-177401671 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027376
 protein coding gene Chr2:184513119-184541198 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024746
 protein coding gene Chr2:165042471-165064951 (-)
CAST/EiJ MGP_CASTEiJ_G0026129
 protein coding gene Chr2:178066171-178092164 (-)
CBA/J MGP_CBAJ_G0026648
 protein coding gene Chr2:191404023-191442067 (-)
DBA/2J MGP_DBA2J_G0026786
 protein coding gene Chr2:170899417-170924974 (-)
FVB/NJ MGP_FVBNJ_G0026752
 protein coding gene Chr2:169517272-169541707 (-)
LP/J MGP_LPJ_G0026887
 protein coding gene Chr2:179278171-179304916 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0026771
 protein coding gene Chr2:194344924-194373645 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027433
 protein coding gene Chr2:176998590-177026324 (-)
PWK/PhJ MGP_PWKPhJ_G0025866
 protein coding gene Chr2:170691332-170717356 (-)
SPRET/EiJ MGP_SPRETEiJ_G0025666
 protein coding gene Chr2:175998553-176024554 (-)
WSB/EiJ MGP_WSBEiJ_G0026202
 protein coding gene Chr2:177955399-177981151 (-)



Homology
more
  • Human Ortholog
    CTCFL, CCCTC-binding factor like
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTCFL, CCCTC-binding factor like
  • Synonyms
    BORIS, CT27, CTCF-T, dJ579F20.2, HMGB1L1
  • Links
    NCBI Gene ID: 140690
    neXtProt AC: NX_Q8NI51
    UniProt: Q8NI51

  • Chr Location
    20q13.31; chr20:57495965-57525652 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit small testes, delayed spermatid development, and increased male germ cell apoptosis without affecting fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    853
  • Tissues
    102
  • cDNA Data
    2
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 664799 NCBI Gene Model | MGI Sequence Detail 25917 C57BL/6J ±  kb
    transcript NM_001355185 RefSeq | MGI Sequence Detail 3247 C57BL/6  
    polypeptide A2APF3 UniProt | EBI | MGI Sequence Detail 636 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR036236 Zinc finger C2H2 superfamily
      IPR013087 Zinc finger C2H2-type
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 2
      Primer pair 1

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:3650163
    References
    more
    • Summaries
      All 28
      Developmental Gene Expression 3
      Gene Ontology 6
      Phenotypes 7
    • Earliest
      J:112166 Loukinov DI, et al., BORIS, a novel male germ-line-specific protein associated with epigenetic reprogramming events, shares the same 11-zinc-finger domain with CTCF, the insulator protein involved in reading imprinting marks in the soma. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6806-11
    • Latest
      J:307511 Rivero-Hinojosa S, et al., The combined action of CTCF and its testis-specific paralog BORIS is essential for spermatogenesis. Nat Commun. 2021 Jun 22;12(1):3846
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/12/2024
    MGI 6.24     		The Jackson Laboratory