Tg(tetO-CDK5R1/GFP)337Lht
Transgene Detail

Summary

• Symbol: Tg(tetO-CDK5R1/GFP)337Lht
• Name: transgene insertion 337, Li-Huei Tsai
• MGI ID: MGI:3653679
• Synonyms: CK-p25 Tg, p25(337), p25-CK, p25-GFP, tetO-p25-GFP, Tg(tetO-p25/GFP)33Lth
• Transgene: Tg(tetO-CDK5R1/GFP)337Lht Location: unknown
• Alliance: Tg(tetO-CDK5R1/GFP)337Lht page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-CDK5R1/GFP)337Lht expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CDK5R1 (8851)

  Cdk5r1

  (MGI:101764)

• Mutation details: The transgene expresses the carboxy-terminal proteolytic fragment (p25) of human cyclin-dependent kinase 5, regulatory subunit 1, bearing a carboxy-terminal green fluorescent protein (GFP) tag, under control of the tetracycline operator. The purpose of the GFP tag is to differentiate immunologically the transgene-encoded p25 from the endogenous p35 protein. (J:104240)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:104240 Cruz JC, et al., Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron. 2003 Oct 30;40(3):471-83
• All: 30 reference(s)