Tg(KRT14-Vegfa)3Dtm
Transgene Detail

Summary

• Symbol: Tg(KRT14-Vegfa)3Dtm
• Name: transgene insertion 3, Michael Detmar
• MGI ID: MGI:3655101
• Synonyms: K14-VEGF, K14/VEGF-A
• Transgene: Tg(KRT14-Vegfa)3Dtm Location: unknown
• Alliance: Tg(KRT14-Vegfa)3Dtm page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT14-Vegfa)3Dtm expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Vegfa (MGI:103178)

• Mutation details: cDNA encoding murine VEGF₁₆₄ was inserted behind a keratin-14 expression cassette. The purified construct was injected into fertilized FVB/N embryos that were implanted into pseudo-pregnant C21 females. In situ analysis of transgenic mice confired selectively increased VEGF expression in the basal keratinocyte layer of the epidermis and in outer sheath keratinocytes of hair follicles. (J:104245)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:104245 Detmar M, et al., Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. J Invest Dermatol. 1998 Jul;111(1):1-6
• All: 18 reference(s)