plt Gene Detail

Summary

• Symbol
  plt
• Name
  paucity of lymph node T cells

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:3664332
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 4, Syntenic

Human Diseases

• Diseases
  1 with plt mouse models

Human Disease

Mouse Models

Sjogren's syndrome

IDs

Sjogren's syndrome      

DOID:12894
DOID:416
ICD10CM:M35.0
ICD9CM:710.2
MESH:D012859
NCI:C26883
NCI:C70647
OMIM:270150
UMLS_CUI:C0086981
UMLS_CUI:C1527336

View 1 model

Mouse Models

Human Disease Modeled: Sjogren's syndrome

Allelic Composition	Genetic Background	Reference	Phenotypes
plt/plt	either: B6.DDD-plt or C.DDD-plt	J:110910	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  30 phenotypes from 1 allele in 4 genetic backgrounds
  80 phenotype references
  

• All Mutations and Alleles
  1
• Spontaneous
  1
• Find Mice (IMSR)
  4 strains or lines available

In homozygous mutant mice, naive T cells fail to localize in the lymph nodes or in the lymphoid regions of the spleen.

References

• Summaries
  All 81

  Diseases 1

  Phenotypes 80
• Earliest
  J:15290 Nakano H, et al., Nonspecific augmentation of lymph node T cells and I-E-independent selective deletion of V beta 14+ T cells by Mtv-2 in the DDD mouse. Eur J Immunol. 1993 Oct;23(10):2434-9
• Latest
  J:341050 Silva-Sanchez A, et al., Activation of regulatory dendritic cells by Mertk coincides with a temporal wave of apoptosis in neonatal lungs. Sci Immunol. 2023 Jun 23;8(84):eadc9081