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Krt87 Gene Detail
Summary
  • Symbol
    Krt87
  • Name
    keratin 87
  • Synonyms
    Krt2-25, Krt83
  • Feature Type
    protein coding gene
  • IDs
    MGI:3665486
    NCBI Gene: 406219
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:101329371-101336685 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 56.90 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    237 from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_3665486
 protein coding gene Chr15:101328919-101336685 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022372
 protein coding gene Chr15:103495012-103505741 (-)
A/J MGP_AJ_G0022334
 protein coding gene Chr15:99399290-99406618 (-)
AKR/J MGP_AKRJ_G0022310
 protein coding gene Chr15:102428052-102436307 (-)
BALB/cJ MGP_BALBcJ_G0022338
 protein coding gene Chr15:99505326-99511887 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0022786
 protein coding gene Chr15:107341836-107350636 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020311
 protein coding gene Chr15:95128677-95135217 (-)
CAST/EiJ MGP_CASTEiJ_G0021633
 protein coding gene Chr15:103383219-103388737 (-)
CBA/J MGP_CBAJ_G0022077
 protein coding gene Chr15:111074503-111086968 (-)
DBA/2J MGP_DBA2J_G0022204
 protein coding gene Chr15:98728232-98736041 (-)
FVB/NJ MGP_FVBNJ_G0022183
 protein coding gene Chr15:97782282-97793747 (-)
LP/J MGP_LPJ_G0022275
 protein coding gene Chr15:103637634-103645202 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022204
 protein coding gene Chr15:114746290-114759685 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022800
 protein coding gene Chr15:102464253-102474385 (-)
PWK/PhJ MGP_PWKPhJ_G0021372
 protein coding gene Chr15:98887973-98897892 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021204
 protein coding gene Chr15:102357347-102365203 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    KRT81, keratin 81
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT81, keratin 81
  • Synonyms
    ghHkb1, Hb-1, HB1, hHAKB2-1, K81, KRTHB1, MLN137
  • Links
    NCBI Gene ID: 3887
    neXtProt AC: NX_Q14533
    UniProt: Q14533

  • Chr Location
    12q13.13; chr12:52285913-52308624 (-)  GRCh38
  • Human Ortholog
    KRT83, keratin 83
  • Synonyms
    EKVP5, Hb-3, HB3, KRTHB3, MNLIX
  • Links
    NCBI Gene ID: 3889
    neXtProt AC: NX_P78385
    UniProt: P78385

  • Chr Location
    12q13.13; chr12:52314301-52321398 (-)  GRCh38
  • Human Ortholog
    KRT86, keratin 86
  • Synonyms
    Hb1, HB6, K86, KRTHB1, KRTHB6, MNX
  • Links
    NCBI Gene ID: 3892
    neXtProt AC: NX_O43790
    UniProt: O43790

  • Chr Location
    12q13.13; chr12:52249300-52309163 (+)  GRCh38
  • Human Ortholog
    KRT87P, keratin 87, pseudogene
  • Synonyms
    KRT121P, KRTHBP4, psihHbD
  • Links
    NCBI Gene ID: 85349
    UniProt: A6NCN2

  • Chr Location
    12q13.13; chr12:52250466-52258553 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human KRT81,KRT83,KRT86 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 406219 NCBI Gene Model | MGI Sequence Detail 7315 C57BL/6J ±  kb
    transcript NM_001003668 RefSeq | MGI Sequence Detail 1826 C57BL/6  
    polypeptide Q6IMF0 UniProt | EBI | MGI Sequence Detail 495 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • InterPro Domains
      IPR018039 Intermediate filament protein, conserved site
      IPR039008 Intermediate filament, rod domain
      IPR003054 Keratin, type II
      IPR032444 Keratin type II head
    Molecular
    Reagents
    less
    • All nucleic 3
      cDNA 3

      Microarray probesets 1
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 3
      Phenotypes 33
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory