Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
Transgene Detail

Summary

• Symbol: Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell
• Name: transgene insertion N8, John F Elliott
• MGI ID: MGI:3590083
• Synonyms: DQ6 transgene, HLA-DQ6 transgene, Tg(CD4,HLA-DQA1*0102,HLADQB1*0602)1Ell
• Transgene: Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell Location: unknown
• Alliance: Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell page

Transgene origin

• Strain of Origin: NOD/ShiLtJ

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Tg(CD4,HLA-DQA1,HLA-DQB1)N8Ell expresses 3 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  CD4 (920)

  Cd4	(MGI:88335)

  human

  HLA-DQA1 (3117)

  H2-Aa

  (MGI:95895)

  human

  HLA-DQB1 (3119)

  H2-Ab1

  (MGI:103070)

• Mutation details: The human CD4 gene lacking one exon but including its promoter was fused downstream of a mouse CD4 enhancer element then mixed with a large DNA fragment containing both HLA-DQA*0102 and HLA-DQB*0602 and injected into NOD/LtJ one celled embryos. A single founder line is maintained. (J:113267)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:113267 Hayward SL, et al., CD4 T cells play major effector role and CD8 T cells initiating role in spontaneous autoimmune myocarditis of HLA-DQ8 transgenic IAb knockout nonobese diabetic mice. J Immunol. 2006 Jun 15;176(12):7715-25
• All: 3 reference(s)