Tg(HLA-DQA1,HLA-DQB1)73Myl
Transgene Detail

Summary

• Symbol: Tg(HLA-DQA1,HLA-DQB1)73Myl
• Name: transgene insertion 73, Myra A Lipes
• MGI ID: MGI:3687023
• Synonyms: HLA-DQ8, HLA-DQ8 line 73
• Transgene: Tg(HLA-DQA1,HLA-DQB1)73Myl Location: unknown
• Alliance: Tg(HLA-DQA1,HLA-DQB1)73Myl page

Transgene origin

• Strain of Origin: B6.129S2-H2-Ab1^b-tm1Gru

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(HLA-DQA1,HLA-DQB1)73Myl expresses 2 genes
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  HLA-DQA1 (3117)

  H2-Aa

  (MGI:95895)

  human

  HLA-DQB1 (3119)

  H2-Ab1

  (MGI:103070)

• Mutation details: The 13.4 kb DQA1*301 and 19.9 kb DQB1*302 genes were subcloned into the pWE15 cosmid. The 33.3 kb fragment was purified and injected into fertilized eggs from H2Ab1^tm1Gru on the C57BL/6 background. (J:88055)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Three separate lines were generated: 70, 73, and 275. Lines 73 and 275 differed primarily in severity of phenotype, with 73 being more severe than 275.

References

• Original: J:88055 Taylor JA, et al., A spontaneous model for autoimmune myocarditis using the human MHC molecule HLA-DQ8. J Immunol. 2004 Feb 15;172(4):2651-8
• All: 1 reference(s)