Tg(Myh6-PRKAG2*R302Q)#Rro
Transgene Detail

Summary

• Symbol: Tg(Myh6-PRKAG2*R302Q)#Rro
• Name: transgene insertion #, Robert Roberts
• MGI ID: MGI:3688892
• Synonyms: TGR302Q
• Transgene: Tg(Myh6-PRKAG2*R302Q)#Rro Location: unknown
• Alliance: Tg(Myh6-PRKAG2*R302Q)#Rro page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-PRKAG2*R302Q)#Rro expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PRKAG2 (51422)

  Prkag2

  (MGI:1336153)

  Transgene codes for a protein with an arginine to glutamine mutation.

• Mutation details: This transgene consists of the human PRKAG2 cDNA with a substitution of an arginine for glutamine at amino acid residue 302 under the control of the cardiac specific alpha-myosin heavy chain promoter. Expression of the transgene was confirmed by Northern analysis. Three lines were made but the reference does not distinguish between them. Data may have been pooled from more than one line. (J:108102)

Disease models

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:108102 Sidhu JS, et al., Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome. Circulation. 2005 Jan 4;111(1):21-9
• All: 1 reference(s)