Tg(Myh6-TNNI3*G203S)1Chs
Transgene Detail

Summary

• Symbol: Tg(Myh6-TNNI3*G203S)1Chs
• Name: transgene insertion 1, Christopher Semsarian
• MGI ID: MGI:3690009
• Synonyms: cTnI-G203S
• Transgene: Tg(Myh6-TNNI3*G203S)1Chs Location: unknown
• Alliance: Tg(Myh6-TNNI3*G203S)1Chs page

Transgene origin

• Strain of Origin: Not Applicable

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-TNNI3*G203S)1Chs expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TNNI3 (7137)

  Tnni3

  (MGI:98783)

  Transgene codes for a protein with a glycine to serine mutation.

• Mutation details: This transgene consists of human TNNI3, with an amino acid substitution of a glycine by serine at codon 203 that causes familial hypertrophic cardiomyopathy in humans, under the control of the cardiac specific alpha-myosin heavy chain promoter. This line expresses the highest amount of mutant protein and represents relative proportions of mutant protein of 83%. (J:114537)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:114537 Tsoutsman T, et al., Molecular insights from a novel cardiac troponin I mouse model of familial hypertrophic cardiomyopathy. J Mol Cell Cardiol. 2006 Oct;41(4):623-32
• All: 10 reference(s)