Tg(MSR1-Plau)1Ddi
Transgene Detail

Summary

• Symbol: Tg(MSR1-Plau)1Ddi
• Name: transgene insertion 1, David A Dichek
• MGI ID: MGI:3690133
• Synonyms: SR-uPA
• Transgene: Tg(MSR1-Plau)1Ddi Location: unknown
• Alliance: Tg(MSR1-Plau)1Ddi page

Transgene origin

• Strain of Origin: C57BL/6 x SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(MSR1-Plau)1Ddi expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Plau (MGI:97611)

• Mutation details: This transgene consists of the mouse Plau gene under the control of the human scavenger receptor A promoter and enhancer, resulting in macrophage specific transgene expression. mRNA expression is increased 40-fold and activity is elevated as much as 500-fold in stimulated peritoneal macrophages. (J:102208)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:102208 Cozen AE, et al., Macrophage-targeted overexpression of urokinase causes accelerated atherosclerosis, coronary artery occlusions, and premature death. Circulation. 2004 May 4;109(17):2129-35
• All: 10 reference(s)